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Immunotherapy in the treatment of non-small cell lung cancer

Authors
 Raghav Sundar  ;  Richie Soong  ;  Byoung-Chul Cho  ;  Julie R. Brahmer  ;  Ross A. Soo 
Citation
 LUNG CANCER, Vol.85(2) : 101-109, 2014 
Journal Title
LUNG CANCER
ISSN
 0169-5002 
Issue Date
2014
MeSH
Animals ; Antibodies, Monoclonal/therapeutic use ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/immunology* ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/therapy* ; Carrier Proteins/metabolism ; Costimulatory and Inhibitory T-Cell Receptors/genetics ; Costimulatory and Inhibitory T-Cell Receptors/metabolism ; Humans ; Immunotherapy* ; Lung Neoplasms/genetics ; Lung Neoplasms/immunology* ; Lung Neoplasms/metabolism ; Lung Neoplasms/therapy* ; Protein Binding
Keywords
CTLA-4 ; Immunotherapy ; Ipilimumab ; Nivolumab ; Non-small cell lung cancer ; PD-L1
Abstract
Advances in the understanding of the role of the immune system in tumor immunosurveillance have resulted in the recognition that tumors can evade immune destruction via the dysregulation of co-inhibitory or checkpoint signals. This has led to the development of a generation immunotherapeutic agents targeting the immune checkpoint pathway. Recent early phase studies of immune checkpoint modulators, such as CTLA-4, PD-1 and PD-L1 inhibitors in NSCLC have reported promising results with prolonged clinical responses and tolerable toxicity. This article provides an overview of co-stimulatory and inhibitory molecules that regulate the immune response to tumors, recent therapies that have been developed to exploit these interactions and the role of predictive biomarkers in treatment selection.
Full Text
http://www.sciencedirect.com/science/article/pii/S0169500214002141
DOI
10.1016/j.lungcan.2014.05.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99580
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