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Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients: a pilot study

 Jin Young Park  ;  Hae-Jeong Park  ;  Dae-Jin Kim  ;  Jae-Jin Kim 
 PSYCHIATRY RESEARCH, Vol.224(1) : 49-57, 2014 
Journal Title
Issue Date
Adult ; Anisotropy* ; Axons ; Brain/ultrastructure ; Diffusion ; Diffusion Tensor Imaging* ; Female ; Humans ; Male ; Middle Aged ; Nerve Fibers, Myelinated/chemistry ; Nerve Fibers, Myelinated/ultrastructure* ; Pilot Projects ; Prefrontal Cortex/chemistry ; Prefrontal Cortex/ultrastructure* ; Schizophrenia/metabolism ; Schizophrenia/pathology* ; Schizophrenic Psychology* ; Severity of Illness Index ; Temporal Lobe/chemistry ; Temporal Lobe/ultrastructure* ; Water*
Diffusion tensor imaging ; Gray matter ; Positive symptoms ; Schizophrenia ; Water diffusivity
The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between water diffusivity and symptom severity in schizophrenia. The present study aimed to examine microstructural deficits in the dorsal prefrontal cortex (DPFC) and temporal cortex in schizophrenia patients using fractional anisotropy (FA) and water diffusivity. This study also explored the relationship between DTI measurements and psychotic symptoms. Magnetic resonance imaging (MRI) and DTI were used to study 19 schizophrenia patients and 19 healthy controls. Fractional anisotropy, axial diffusivity, radial diffusivity, and regional volumes were measured in the prefrontal cortex and temporal cortex. On DTI measurements, patients showed increased axial and radial diffusivities in the prefrontal cortex and temporal cortex, but they did not demonstrate any difference in fractional anisotropy and regional volumes. Additionally, axial and radial diffusivities were significantly correlated with positive symptom scores in all regions of interest. These results indicate that water diffusivity measurements, including axial and radial diffusivities, can be used to identify microstructural changes in the gray matter in schizophrenia that may be related to symptom severity.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
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