Cited 6 times in
Anti-obesity effects of KR-66195, a synthetic DPP-IV inhibitor, in diet-induced obese mice and obese-diabetic ob/ob mice
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김연욱 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이은영 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-01-06T17:13:13Z | - |
dc.date.available | 2015-01-06T17:13:13Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99561 | - |
dc.description.abstract | OBJECTIVE: We investigated whether KR-66195, a new synthetic dipeptidyl dipeptidase IV inhibitor, could prevent weight gain, as well as improving glycemic control in diet-induced obese (DIO) and ob/ob mice. MATERIALS/METHODS: Male C57BL/6 mice were randomly assigned to the following groups: chow diet, high-fat diet, and high-fat diet with KR-66195. After KR-66195 treatment for eight weeks, intraperitoneal glucose tolerance tests were performed. A pair-feeding study was performed to investigate the mechanisms of the anti-obesity effects of KR-66195 in DIO mice. Female ob/ob mice were treated with KR-66195 for three weeks and compared to the vehicle-treated group. RESULTS: In DIO mice, KR-66195 treatment increased the plasma glucagon-like peptide (GLP)-1 levels and improved glucose tolerance. This treatment also reduced body weight gain (5.38±0.94 g vs. 12.08±0.55 g, P<0.01) and food intake (2.41±0.09 g vs. 2.79±0.11 g, P<0.05). In ob/ob mice, KR-66195 treatment for three weeks resulted in comparable effects in DIO mice. In the pair-feeding study, KR-66195-treated mice exhibited a 16% increase in energy expenditure (kcal/h/kg lean body mass) without significant differences in body weight or activities compared with pair-fed mice. These results suggest that KR-66195 prevented weight gain in DIO mice by decreasing food intake, as well as increasing energy expenditure. CONCLUSIONS: KR-66195 markedly increased plasma levels of GLP-1, resulting in the probable improvement in glucose tolerance and reduced body weight and food intake. Thus, KR-66195 might be further developed as a therapeutic drug to treat obesity, as well as diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 793~799 | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Obesity Agents/pharmacology* | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Body Composition/drug effects | - |
dc.subject.MESH | Diabetes Mellitus/prevention & control | - |
dc.subject.MESH | Diet, High-Fat | - |
dc.subject.MESH | Dipeptidyl Peptidase 4/drug effects* | - |
dc.subject.MESH | Eating/drug effects | - |
dc.subject.MESH | Energy Metabolism/drug effects | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucagon-Like Peptide 1/blood | - |
dc.subject.MESH | Glucose Tolerance Test/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Obese | - |
dc.subject.MESH | Obesity/blood | - |
dc.subject.MESH | Obesity/drug therapy | - |
dc.subject.MESH | Obesity/etiology | - |
dc.subject.MESH | Obesity/prevention & control* | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Thiazolidines/pharmacology* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Valine/analogs & derivatives* | - |
dc.subject.MESH | Valine/pharmacology | - |
dc.subject.MESH | Weight Gain/drug effects* | - |
dc.title | Anti-obesity effects of KR-66195, a synthetic DPP-IV inhibitor, in diet-induced obese mice and obese-diabetic ob/ob mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Yeon Wook Kim | - |
dc.contributor.googleauthor | Hyunhee Oh | - |
dc.contributor.googleauthor | Cheol Soo Choi | - |
dc.contributor.googleauthor | Jin Hee Ahn | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.1016/j.metabol.2014.02.011 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00692 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A03042 | - |
dc.relation.journalcode | J02223 | - |
dc.identifier.eissn | 1532-8600 | - |
dc.identifier.pmid | 24684824 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S002604951400050X | - |
dc.subject.keyword | Diabetes | - |
dc.subject.keyword | Dipeptidyl peptidase (DPP)-IV | - |
dc.subject.keyword | Glucagon-like peptide (GLP)-1 | - |
dc.subject.keyword | KR-66195 | - |
dc.subject.keyword | Obesity | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Yeon Wook | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Eung Young | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Yeon Wook | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Lee, Eun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 63 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 793 | - |
dc.citation.endPage | 799 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.63(6) : 793-799, 2014 | - |
dc.identifier.rimsid | 38918 | - |
dc.type.rims | ART | - |
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