3 251

Cited 0 times in

Analytical and Clinical Performance of a New Point of Care LABGEOIB D-Dimer Test for Diagnosis of Venous Thromboembolism

DC FieldValueLanguage
dc.contributor.author권태동-
dc.contributor.author송예진-
dc.contributor.author송재우-
dc.date.accessioned2015-01-06T17:10:17Z-
dc.date.available2015-01-06T17:10:17Z-
dc.date.issued2014-
dc.identifier.issn0091-7370-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99467-
dc.description.abstractLABGEO(IB) D-dimer Test is a newly developed POC D-dimer assay and the first commercially available POC immunoassay instrument that exploits the disk rotation method for extraction of plasma. Citrate plasma was obtained from 201 apparently healthy subjects and 91 patients suspected for VTE, and their D-dimer level was measured by the LABGEO(IB) D-Dimer Test (LABGEO D-dimer) and HemosIL D-dimer test as a comparative method. To examine the effect of blood cells and anticoagulant, paired blood samples anticoagulated by heparin and citrate were obtained from various postoperative patients. The overall diagnostic performance of LABGEO(IB) D-dimer and HemosIL was comparable with similar area under ROC curve (p=0.79). The cut-off levels recommended by manufacturers (LABGEO D-dimer: 0.45 μg/ml fibrinogen equivalent unit (FEU), HemosIL: 0.23 μg/ml D-dimer unit (DDU)) and those yielding highest diagnostic efficiency (LABGEO D-dimer: 1.41 μg/ml FEU; HemosIL: 0.85 μg/ml DDU), were chosen for the evaluation. For LABGEO D-dimer negative predictive value (NPV), positive predictive value (PPV), sensitivity, specificity, and negative likelihood ratio (LR-neg) were 93-100%, 67-89%, 93-100%, 53-89% and 0.00-0.08. For HemosIL D-dimer, NPV, PPV, sensitivity, specificity and LR-neg were 90 - 100%, 76-95%, 89-100%, 70-96% and 0.00-0.12, all comparable to results for LABGEO D-dimer. LABGEO D-dimer test demonstrated acceptable performance when used for the VTE diagnostic work-up.-
dc.description.statementOfResponsibilityopen-
dc.format.extent254~261-
dc.relation.isPartOfANNALS OF CLINICAL AND LABORATORY SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBlood Chemical Analysis/methods*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDimerization-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoassay-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPoint-of-Care Systems-
dc.subject.MESHReference Standards-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHVenous Thromboembolism/blood-
dc.subject.MESHVenous Thromboembolism/diagnosis*-
dc.titleAnalytical and Clinical Performance of a New Point of Care LABGEOIB D-Dimer Test for Diagnosis of Venous Thromboembolism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJaewoo Song-
dc.contributor.googleauthorTae Dong Kweon-
dc.contributor.googleauthorYeajin Song-
dc.contributor.googleauthorEun Young Lee-
dc.contributor.googleauthorSue Jung Kim-
dc.contributor.googleauthorRojin Park-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00255-
dc.contributor.localIdA02041-
dc.contributor.localIdA02054-
dc.relation.journalcodeJ00155-
dc.identifier.eissn1550-8080-
dc.identifier.pmid25117092-
dc.identifier.urlhttp://www.annclinlabsci.org/content/44/3/254.full.pdf+html-
dc.subject.keywordLABGEOIB D-dimer Test-
dc.subject.keywordpoint-of-care-
dc.subject.keywordvenous thromboembolism-
dc.contributor.alternativeNameKweon, Tae Dong-
dc.contributor.alternativeNameSong, Yea Jin-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.affiliatedAuthorKweon, Tae Dong-
dc.contributor.affiliatedAuthorSong, Yea Jin-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.rights.accessRightsfree-
dc.citation.volume44-
dc.citation.number3-
dc.citation.startPage254-
dc.citation.endPage261-
dc.identifier.bibliographicCitationANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.44(3) : 254-261, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.