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Long-term changes of liver stiffness values assessed using transient elastography in patients with chronic hepatitis B receiving entecavir

 Mi Na Kim  ;  Seung Up Kim  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han 
 LIVER INTERNATIONAL, Vol.34(8) : 1216-1223, 2014 
Journal Title
Issue Date
Area Under Curve ; Elasticity Imaging Techniques/methods ; Female ; Guanine/analogs & derivatives* ; Guanine/pharmacology ; Guanine/therapeutic use ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy* ; Hepatitis B, Chronic/pathology* ; Humans ; Liver/diagnostic imaging* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/etiology ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea ; Statistics, Nonparametric
chronic hepatitis B ; entecavir ; hepatitis B virus ; liver stiffness ; longitudinal ; transient elastography
BACKGROUND & AIMS: Liver stiffness (LS) measurement using transient elastography allows for accurate evaluation of liver fibrosis in patients with chronic liver disease. We aimed to investigate the influence of antiviral treatment using entecavir (ETV) on LS values in patients with chronic hepatitis B (CHB). METHODS: 121 patients with CHB who completed a 3-year ETV treatment were recruited. LS values were measured before starting ETV (baseline) and after the completion of the 3-year treatment. A significant decline in the LS value was defined as a ≥30% drop from the baseline. RESULTS: The median baseline LS value of the patients was 14.3 kPa. However, it decreased significantly to 7.3 kPa after 3-year ETV treatment (P < 0.001). A higher baseline LS value was the single independent predictor of a significant decline in LS value on multivariate analysis (P<0.001; hazard ratio [HR], 1.155; 95% confidence interval [CI], 1.073-1.243). Using an optimal cutoff baseline LS value of 11.5 kPa (area under receiver operating characteristic curve, 0.781; 95% CI, 0.698-0.863, P < 0.001; sensitivity 75.6%; specificity, 62.8%), patients with baseline LS values of ≥11.5 kPa had a greater probability of experiencing a significant decline in the LS value than those with baseline LS values of <11.5 kPa (P < 0.001; HR, 5.240; 95% CI, 2.340-11.732). CONCLUSIONS: In patients with CHB, LS values were decreased significantly after a 3-year ETV treatment. A higher baseline LS value was the single independent predictor of a significant decline in the LS value.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Mi Na(김미나)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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