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Short Communication: Prospective Comparison of Qualitative Versus Quantitative Polymerase Chain Reaction for Monitoring Virologic Treatment Failure in HIV-Infected Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민형 | - |
dc.contributor.author | 김선빈 | - |
dc.contributor.author | 김재경 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 송제은 | - |
dc.contributor.author | 안진영 | - |
dc.contributor.author | 안혜원 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 최흔 | - |
dc.contributor.author | 한상훈 | - |
dc.contributor.author | 구남수 | - |
dc.date.accessioned | 2015-01-06T17:06:57Z | - |
dc.date.available | 2015-01-06T17:06:57Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0889-2229 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99371 | - |
dc.description.abstract | Less costly but still accurate methods for monitoring HIV treatment response are needed. We prospectively evaluated if a qualitative polymerase chain reaction (PCR) amplification assay for virologic monitoring could maintain accuracy while reducing costs in Seoul, South Korea. We conducted the first prospective study comparing a qualitative PCR amplification of HIV-1 reverse transcriptase (RT) versus a commercial real time PCR assay (i.e., viral load) for virologic monitoring of 150 patients receiving antiretroviral therapy (ART) between November 2011 and August 2012 at an urban hospital in Seoul, South Korea. A total of 215 blood plasma samples from 150 patients receiving ART for more than 6 months were evaluated. Using the individual viral load assay, 12 of 215 (5.6%) plasma samples had more than 500 HIV RNA copies/ml. The qualitative PCR amplification assay detected individual samples with ≥500 HIV RNA copies/ml with 100% sensitivity. The specificities of the qualitative PCR amplification of the HIV-1 RT assay were 94.1%, 93.6%, and 93.2% compared to the real time PCR at 500, 1,000, and 5,000 threshold of HIV RNA copies/ml, respectively, and $24,940 USD would have been saved for 150 patients during 10 months. The qualitative PCR amplification of the HIV-1 RT assay might be a useful approach to effectively monitor patients receiving ART and save resources. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 827~829 | - |
dc.relation.isPartOf | AIDS RESEARCH AND HUMAN RETROVIRUSES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Anti-HIV Agents/therapeutic use* | - |
dc.subject.MESH | Drug Monitoring/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections/drug therapy* | - |
dc.subject.MESH | HIV Infections/virology* | - |
dc.subject.MESH | HIV-1/genetics | - |
dc.subject.MESH | HIV-1/isolation & purification* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymerase Chain Reaction/methods* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Treatment Failure | - |
dc.subject.MESH | Viral Load/methods* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Short Communication: Prospective Comparison of Qualitative Versus Quantitative Polymerase Chain Reaction for Monitoring Virologic Treatment Failure in HIV-Infected Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jeong Su Jin | - |
dc.contributor.googleauthor | Kim Min Hyung | - |
dc.contributor.googleauthor | Song Je Eun | - |
dc.contributor.googleauthor | Ahn Jin Young | - |
dc.contributor.googleauthor | Kim Sun Bean | - |
dc.contributor.googleauthor | Ann Hea Won | - |
dc.contributor.googleauthor | Kim Jae Kyung | - |
dc.contributor.googleauthor | Choi Heun | - |
dc.contributor.googleauthor | Ku Nam Su | - |
dc.contributor.googleauthor | Han Sang Hoon | - |
dc.contributor.googleauthor | Kim June Myung | - |
dc.contributor.googleauthor | Smith Davey M. | - |
dc.contributor.googleauthor | Kim Hyon-Suk | - |
dc.contributor.googleauthor | Choi Jun Yong | - |
dc.identifier.doi | 10.1089/aid.2013.0227 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00480 | - |
dc.contributor.localId | A00547 | - |
dc.contributor.localId | A00856 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A02059 | - |
dc.contributor.localId | A02267 | - |
dc.contributor.localId | A02275 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04227 | - |
dc.contributor.localId | A04286 | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J00055 | - |
dc.identifier.eissn | 1931-8405 | - |
dc.identifier.pmid | 24724838 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/aid.2013.0227 | - |
dc.contributor.alternativeName | Kim, Min Hyung | - |
dc.contributor.alternativeName | Kim, Sun Bean | - |
dc.contributor.alternativeName | Kim, Jae Kyoung | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Song, Je Eun | - |
dc.contributor.alternativeName | Ahn, Jin Young | - |
dc.contributor.alternativeName | Ann, Hea Won | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Choi, Heun | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | Kim, Min Hyung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Bean | - |
dc.contributor.affiliatedAuthor | Kim, Jae Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Song, Je Eun | - |
dc.contributor.affiliatedAuthor | Ahn, Jin Young | - |
dc.contributor.affiliatedAuthor | Ann, Hea Won | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Choi, Heun | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 827 | - |
dc.citation.endPage | 829 | - |
dc.identifier.bibliographicCitation | AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.30(8) : 827-829, 2014 | - |
dc.identifier.rimsid | 57222 | - |
dc.type.rims | ART | - |
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