0 266

Cited 1 times in

Short Communication: Prospective Comparison of Qualitative Versus Quantitative Polymerase Chain Reaction for Monitoring Virologic Treatment Failure in HIV-Infected Patients

DC FieldValueLanguage
dc.contributor.author김민형-
dc.contributor.author김선빈-
dc.contributor.author김재경-
dc.contributor.author김준명-
dc.contributor.author김현숙-
dc.contributor.author송제은-
dc.contributor.author안진영-
dc.contributor.author안혜원-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author최흔-
dc.contributor.author한상훈-
dc.contributor.author구남수-
dc.date.accessioned2015-01-06T17:06:57Z-
dc.date.available2015-01-06T17:06:57Z-
dc.date.issued2014-
dc.identifier.issn0889-2229-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99371-
dc.description.abstractLess costly but still accurate methods for monitoring HIV treatment response are needed. We prospectively evaluated if a qualitative polymerase chain reaction (PCR) amplification assay for virologic monitoring could maintain accuracy while reducing costs in Seoul, South Korea. We conducted the first prospective study comparing a qualitative PCR amplification of HIV-1 reverse transcriptase (RT) versus a commercial real time PCR assay (i.e., viral load) for virologic monitoring of 150 patients receiving antiretroviral therapy (ART) between November 2011 and August 2012 at an urban hospital in Seoul, South Korea. A total of 215 blood plasma samples from 150 patients receiving ART for more than 6 months were evaluated. Using the individual viral load assay, 12 of 215 (5.6%) plasma samples had more than 500 HIV RNA copies/ml. The qualitative PCR amplification assay detected individual samples with ≥500 HIV RNA copies/ml with 100% sensitivity. The specificities of the qualitative PCR amplification of the HIV-1 RT assay were 94.1%, 93.6%, and 93.2% compared to the real time PCR at 500, 1,000, and 5,000 threshold of HIV RNA copies/ml, respectively, and $24,940 USD would have been saved for 150 patients during 10 months. The qualitative PCR amplification of the HIV-1 RT assay might be a useful approach to effectively monitor patients receiving ART and save resources.-
dc.description.statementOfResponsibilityopen-
dc.format.extent827~829-
dc.relation.isPartOfAIDS Research and Human Retroviruses-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleShort Communication: Prospective Comparison of Qualitative Versus Quantitative Polymerase Chain Reaction for Monitoring Virologic Treatment Failure in HIV-Infected Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJeong Su Jin-
dc.contributor.googleauthorKim Min Hyung-
dc.contributor.googleauthorSong Je Eun-
dc.contributor.googleauthorAhn Jin Young-
dc.contributor.googleauthorKim Sun Bean-
dc.contributor.googleauthorAnn Hea Won-
dc.contributor.googleauthorKim Jae Kyung-
dc.contributor.googleauthorChoi Heun-
dc.contributor.googleauthorKu Nam Su-
dc.contributor.googleauthorHan Sang Hoon-
dc.contributor.googleauthorKim June Myung-
dc.contributor.googleauthorSmith Davey M.-
dc.contributor.googleauthorKim Hyon-Suk-
dc.contributor.googleauthorChoi Jun Yong-
dc.identifier.doi10.1089/aid.2013.0227-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00480-
dc.contributor.localIdA00547-
dc.contributor.localIdA00856-
dc.contributor.localIdA00953-
dc.contributor.localIdA02059-
dc.contributor.localIdA02267-
dc.contributor.localIdA02275-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04227-
dc.contributor.localIdA04286-
dc.contributor.localIdA00189-
dc.contributor.localIdA01117-
dc.relation.journalcodeJ00055-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/aid.2013.0227-
dc.contributor.alternativeNameKim, Min Hyung-
dc.contributor.alternativeNameKim, Sun Bean-
dc.contributor.alternativeNameKim, Jae Kyoung-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNameSong, Je Eun-
dc.contributor.alternativeNameAhn, Jin Young-
dc.contributor.alternativeNameAnn, Hea Won-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameChoi, Heun-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Min Hyung-
dc.contributor.affiliatedAuthorKim, Sun Bean-
dc.contributor.affiliatedAuthorKim, Jae Kyoung-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorSong, Je Eun-
dc.contributor.affiliatedAuthorAhn, Jin Young-
dc.contributor.affiliatedAuthorAnn, Hea Won-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorChoi, Heun-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Hyon Suk-
dc.rights.accessRightsfree-
dc.citation.volume30-
dc.citation.number8-
dc.citation.startPage827-
dc.citation.endPage829-
dc.identifier.bibliographicCitationAIDS Research and Human Retroviruses, Vol.30(8) : 827-829, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.