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Modifying effects of resting heart rate on the association of binge drinking with all-cause and cardiovascular mortality in older Korean men: The Kangwha cohort study

Authors
 Mikyung Ryu  ;  Bayasgalan Gombojav  ;  Chung Mo Nam  ;  Yunhwan Lee  ;  Kimyoung Han 
Citation
 JOURNAL OF EPIDEMIOLOGY, Vol.24(4) : 274-280, 2014 
Journal Title
JOURNAL OF EPIDEMIOLOGY
ISSN
 0917-5040 
Issue Date
2014
MeSH
Aged ; Binge Drinking/physiopathology* ; Cardiovascular Diseases/mortality* ; Cause of Death/trends ; Cohort Studies ; Heart Rate/physiology* ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Republic of Korea/epidemiology ; Risk Factors
Keywords
alcohol drinking ; binge drinking ; cardiovascular disease ; mortality ; resting heart rate
Abstract
Background: Although binge drinking and high resting heart rate independently affect cardiovascular and all-cause mortality risk, the combined effect of these two risk factors and their interaction has rarely been studied. This study examined the association between binge drinking and cardiovascular and all-cause mortality and evaluated the potential modifying effect on this association of resting heart rate in Korean men.
Methods: Men aged 55 years or older in 1985 (n = 2600) were followed for cardiovascular and all-cause mortality for 20.8 years, until 2005. We estimated hazard ratios (HRs) for cardiovascular and all-cause mortality by binge drinking and resting heart rate using the Cox proportional hazard model.
Results: Heavy binge drinkers (≥12 drinks on one occasion) with elevated resting heart rate (≥80 bpm) had a HR of 2.25 (95% confidence interval [CI], 1.47–3.45) for death from cardiovascular disease and 1.37 (95% CI, 0.87–2.14) for all-cause mortality compared to the reference group (non-drinking and resting heart rate 61–79 bpm). The HRs of dying from cardiovascular disease increased linearly from 1.36 to 1.52, 1.71, and 2.25 among individuals with resting heart rate greater than or equal to 80 bpm within the four alcohol consumption categories (non-drinking, non-binge, moderate binge, and heavy binge), respectively.
Conclusions: Our findings suggest that, among older Korean men, heavy binge drinkers with an elevated resting heart rate are at high risk for cardiovascular and all-cause mortality.
Files in This Item:
T201402368.pdf Download
DOI
10.2188/jea.JE20130101
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99298
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