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Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis

Authors
 Ji Eun Kim  ;  Sang Kee Min  ;  Yun Jeong Chae  ;  Yeon Ju Lee  ;  Bong Ki Moon  ;  Jong Yeop Kim 
Citation
 JOURNAL OF ANESTHESIA, Vol.28(2) : 257-266, 2014 
Journal Title
 JOURNAL OF ANESTHESIA 
ISSN
 0913-8668 
Issue Date
2014
MeSH
Administration, Intravenous ; Adrenergic Agonists/therapeutic use ; Adult ; Anesthetics, Intravenous/administration & dosage ; Anesthetics, Intravenous/adverse effects* ; Anesthetics, Local/therapeutic use ; Cough/chemically induced* ; Cough/etiology ; Cough/prevention & control* ; Fentanyl/administration & dosage ; Fentanyl/adverse effects* ; Humans ; Lidocaine/therapeutic use ; Propofol/therapeutic use ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
Keywords
Anesthesia ; Fentanyl-induced cough ; Meta-analysis ; Prevention
Abstract
Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and nonpharmacological interventions to reduce the incidence of FIC. We searched for randomized controlled trials comparing pharmacological or nonpharmacological interventions with controls to prevent FIC; we included 28 studies retrieved from PubMed, Embase, and Cochrane Library. Overall incidence of FIC was approximately 31 %. Lidocaine [odds ratio (OR) = 0.29, 95 % confidence interval (CI) 0.21–0.39], N-methyl-D-aspartate (NMDA) receptor antagonists (OR 0.09, 95 % CI 0.02–0.42), propofol (OR 0.07, 95 % CI 0.01–0.36), α2 agonists (OR 0.32, 95 % CI 0.21–0.48), β2 agonists (OR 0.10, 95 % CI 0.03–0.30), fentanyl priming (OR 0.33, 95 % CI 0.19–0.56), and slow injection of fentanyl (OR 0.25, 95 % CI 0.11–0.58)] were effective in decreasing the incidence of FIC, whereas atropine (OR 1.10, 95 % CI 0.58–2.11) and benzodiazepines (OR 2.04, 95 % CI 1.33–3.13) were not effective. This meta-analysis found that lidocaine, NMDA receptor antagonists, propofol, α2 agonists, β2 agonists, and priming dose of fentanyl were effective in preventing FIC, but atropine and benzodiazepines were not. Slow injection of fentanyl was effective in preventing FIC, but results depend on the speed of administration.
Full Text
http://link.springer.com/article/10.1007%2Fs00540-013-1695-4
DOI
10.1007/s00540-013-1695-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Eun(김지은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99262
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