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사회불안장애에서 편도 하위영역의 내재 기능적 연결성의 특성

Other Titles
 Characteristics of Intrinsic Functional Connectivity of Amygdalar Subregions in Social Anxiety Disorder 
 김진성  ;  윤형준  ;  박선영  ;  신유빈  ;  김재진 
 Anxiety and Mood (대한불안의학회지), Vol.10(1) : 44-51, 2014 
Journal Title
Anxiety and Mood(대한불안의학회지)
Issue Date
Social anxiety disorder ; Amygdalar subregions ; Functional connectivity ; Functional magnetic resonance imaging ; Cognitive bias
Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous functional neuroimaging studies. Methods : Resting-state functional magnetic resonance imaging data was obtained in 19 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and perigenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality in superficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Yoon, Hyung Jun(윤형준)
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