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18F-FDG PET as a single imaging modality in pediatric neuroblastoma: comparison with abdomen CT and bone scintigraphy

 Yun Jung Choi  ;  Hee Sung Hwang  ;  Hyun Jeong Kim  ;  Yong Hyu Jeong  ;  Arthur Cho  ;  Jae Hoon Lee  ;  Mijin Yun  ;  Jong Doo Lee  ;  Won Jun Kang 
 ANNALS OF NUCLEAR MEDICINE, Vol.28(4) : 304-313, 2014 
Journal Title
Issue Date
Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/secondary ; Bone and Bones/diagnostic imaging ; Child, Preschool ; Female ; Fluorodeoxyglucose F18 ; Ganglioneuroblastoma/diagnostic imaging ; Humans ; Image Interpretation, Computer-Assisted ; Infant ; Infant, Newborn ; Lymph Nodes/diagnostic imaging ; Lymphatic Metastasis/diagnostic imaging ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Staging ; Neuroblastoma/diagnostic imaging* ; Positron-Emission Tomography* ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed
Neuroblastoma ; 18F-fluoro-2-deoxy-Dglucose positron emission tomography (18F-FDG PET) ; Bone metastasis ; Bone scintigraphy
OBJECTIVE:The purpose of this study was to evaluate the diagnostic performance of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a single imaging agent in neuroblastoma in comparison with other imaging modalities.
METHODS:A total of 30 patients with pathologically proven neuroblastoma who underwent FDG PET for staging were enrolled. Diagnostic performance of FDG PET and abdomen CT was compared in detecting soft tissue lesions. FDG PET and bone scintigraphy (BS) were compared in bone metastases. Maximal standardized uptake value (SUVmax) of primary or recurrent lesions was calculated for quantitative analysis.
RESULTS:Tumor FDG uptake was detected in 29 of 30 patients with primary neuroblastoma. On initial FDG PET, SUVmax of primary lesions were lower in early stage (I-II) than in late stage (III-IV) (3.03 vs. 5.45, respectively, p = 0.019). FDG PET was superior to CT scan in detecting distant lymph nodes (23 vs. 18 from 23 lymph nodes). FDG PET showed higher accuracy to identify bone metastases than BS both on patient-based analyses (100 vs. 94.4 % in sensitivity, 100 vs. 77.8 % in specificity), and on lesion-based analyses (FDG PET: 203 lesions, BS: 86 lesions). Sensitivity and specificity of FDG PET to detect recurrence were 87.5 % and 93.8, respectively.
CONCLUSION:FDG PET was superior to CT in detecting distant LN metastasis and to BS in detecting skeletal metastasis in neuroblastoma. BS might be eliminated in the evaluation of neuroblastoma when FDG PET is performed.
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo
Kim, Hyun Jeong(김현정) ORCID logo
Yun, Mi Jin(윤미진) ORCID logo
Lee, Jae Hoon(이재훈) ORCID logo
Lee, Jong Doo(이종두)
Jeong, Yong Hyu(정용휴) ORCID logo
Cho, Arthur Eung Hyuck(조응혁) ORCID logo
Choi, Yun-Jung(최윤정)
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