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Epidermal Permeability Barrier Defects and Barrier Repair Therapy in Atopic Dermatitis

Authors
 Hae-Jin Lee  ;  Seung-Hun Lee 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.6(4) : 276-287, 2014 
Journal Title
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 
ISSN
 2092-7355 
Issue Date
2014
Keywords
Atopic dermatitis ; barrier repair therapy ; skin barrier
Abstract
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease perpetuated by gene-environmental interactions and which is characterized by genetic barrier defects and allergic inflammation. Recent studies demonstrate an important role for the epidermal permeability barrier in AD that is closely related to chronic immune activation in the skin during systemic allergic reactions. Moreover, acquired stressors (e.g., Staphylococcus aureus infection) to the skin barrier may also initiate inflammation in AD. Many studies involving patients with AD revealed that defective skin barriers combined with abnormal immune responses might contribute to the pathophysiology of AD, supporting the outside-inside hypothesis. In this review, we discuss the recent advances in human and animal models, focusing on the defects of the epidermal permeability barrier, its immunologic role and barrier repair therapy in AD.
Files in This Item:
T201402075.pdf Download
DOI
10.4168/aair.2014.6.4.276
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99119
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