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Impact of Spontaneous Hepatocellular Carcinoma Rupture on Recurrence Pattern and Long-term Surgical Outcomes after Partial Hepatectomy

DC FieldValueLanguage
dc.contributor.author최진섭-
dc.contributor.author한광협-
dc.contributor.author강대용-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이형순-
dc.contributor.author최기홍-
dc.date.accessioned2015-01-06T16:57:14Z-
dc.date.available2015-01-06T16:57:14Z-
dc.date.issued2014-
dc.identifier.issn0364-2313-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99089-
dc.description.abstractBACKGROUND: The clinical significance of spontaneous hepatocellular carcinoma (HCC) rupture association with recurrence pattern and long-term surgical outcomes remains under debate. We investigated the impact of spontaneous HCC rupture on recurrence pattern and long-term surgical outcomes after partial hepatectomy. METHODS: From 2000 to 2012, 119 patients with diagnosed ruptured HCC were reviewed. To compare outcomes between staged hepatectomy in spontaneously ruptured HCC and hepatectomy in non-ruptured HCC, we performed propensity score-matching to adjust for significant differences in patient characteristics. Overall survival, disease-free survival, and recurrence pattern were compared between the matched groups. RESULTS: Forty-four patients with newly diagnosed ruptured HCC and Child A class were initially treated with transcatheter arterial embolization for hemostasis. Three patients underwent emergency laparotomy, 18 underwent staged hepatectomy, and 23 received transarterial chemoembolization (TACE) alone after transcatheter arterial embolization. Among the 23 patients treated with TACE alone, 10 had resectable tumors. The staged hepatectomy group shows significantly higher overall survival with TACE alone than the resectable tumor group (P < 0.001). After propensity score-matching, overall survival, disease-free survival, and recurrence pattern were not significantly different between the ruptured HCC with staged hepatectomy group and the non-ruptured HCC with hepatectomy group. Peritoneal recurrence rates were similar at 14.3% versus 10.0%, respectively (P = 0.632). CONCLUSIONS: Patients with spontaneously ruptured HCC with staged hepatectomy show comparable long-term survival and recurrence pattern as patients with non-ruptured HCC having similar tumor characteristics and liver functional status. Thus, spontaneous HCC rupture may not increase peritoneal recurrence and decrease long-term survival after partial hepatectomy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2070~2078-
dc.relation.isPartOfWorld Journal of Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleImpact of Spontaneous Hepatocellular Carcinoma Rupture on Recurrence Pattern and Long-term Surgical Outcomes after Partial Hepatectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyung Soon Lee-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorDae Ryong Kang-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJin Sub Choi-
dc.identifier.doi10.1007/s00268-014-2502-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04199-
dc.contributor.localIdA04268-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA03304-
dc.contributor.localIdA04046-
dc.contributor.localIdA00009-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02802-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00268-014-2502-6-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKang, Dae Ryong-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Hyung Soon-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Hyung Soon-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorKang, Dae Ryong-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsfree-
dc.citation.volume38-
dc.citation.number8-
dc.citation.startPage2070-
dc.citation.endPage2078-
dc.identifier.bibliographicCitationWorld Journal of Surgery, Vol.38(8) : 2070-2078, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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