481 848

Cited 24 times in

Optimal Proteinuria Target for Renoprotection in Patients with IgA Nephropathy

DC Field Value Language
dc.contributor.author정현주-
dc.contributor.author강신욱-
dc.contributor.author최규헌-
dc.contributor.author강이화-
dc.contributor.author한대석-
dc.contributor.author권영은-
dc.contributor.author한승혁-
dc.contributor.author김동욱-
dc.contributor.author김영리-
dc.contributor.author남기헌-
dc.contributor.author박경숙-
dc.contributor.author박정탁-
dc.contributor.author안성영-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author임범진-
dc.contributor.author장태익-
dc.date.accessioned2015-01-06T16:56:34Z-
dc.date.available2015-01-06T16:56:34Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99068-
dc.description.abstractBACKGROUND: Proteinuria is a target for renoprotection in kidney diseases. However, optimal level of proteinuria reduction in IgA nephropathy (IgAN) is unknown. METHODS: We conducted a retrospective observational study in 500 patients with biopsy-proven IgAN. Time-averaged proteinuria (TA-P) was calculated as the mean of every 6 month period of measurements of spot urine protein-to-creatinine ratio. The study endpoints were a 50% decline in estimated glomerular filtration rate (eGFR), onset of end-stage renal disease (ESRD), and slope of eGFR. RESULTS: During a median follow-up duration of 65 (12-154) months, a 50% decline in eGFR occurred in 1 (0.8%) patient with TA-P of <0.3 g/g compared to 6 (2.7%) patients with TA-P of 0.3-0.99 g/g (hazard ratio, 2.82; P = 0.35). Risk of reaching a 50% decline in eGFR markedly increased in patients with TA-P of 1.0-2.99 g/g (P = 0.002) and those with TA-P≥3.0 g/g (P<0.001). ESRD did not occur in patients with TA-P<1.0 g/g compared to 26 (20.0%) and 8 (57.1%) patients with TA-P of 1.0-2.99 and ≥3.0 g/g, respectively. Kidney function of these two groups deteriorated faster than those with TA-P<1.0 g/g (P<0.001). However, patients with TA-P of 0.3-0.99 g/g had a greater decline of eGFR than patients with TA-P<0.3 g/g (-0.41±1.68 vs. -0.73±2.82 ml/min/1.73 m2/year, P = 0.03). CONCLUSION: In this study, patients with TA-P<1.0 g/g show favorable outcomes. However, given the faster eGFR decline in patients with TA-P of 0.3-0.99 g/g than in patients with TA-P<0.3 g/g, the ultimate optimal goal of proteinuria reduction can be lowered in the management of IgAN.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHGlomerulonephritis, IGA/mortality-
dc.subject.MESHGlomerulonephritis, IGA/therapy-
dc.subject.MESHGlomerulonephritis, IGA/urine*-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHKidney/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProteinuria/mortality-
dc.subject.MESHProteinuria/therapy-
dc.subject.MESHProteinuria/urine*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleOptimal Proteinuria Target for Renoprotection in Patients with IgA Nephropathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKi Heon Nam-
dc.contributor.googleauthorJeong Hae Kie-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorTae-Ik Chang-
dc.contributor.googleauthorEa Wha Kang-
dc.contributor.googleauthorDong Wook Kim-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorYoung Eun Kwon-
dc.contributor.googleauthorYung Ly Kim-
dc.contributor.googleauthorKyoung Sook Park-
dc.contributor.googleauthorSeong Yeong An-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.contributor.googleauthorDae-Suk Han-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1371/journal.pone.0101935-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03771-
dc.contributor.localIdA00053-
dc.contributor.localIdA04043-
dc.contributor.localIdA00074-
dc.contributor.localIdA04272-
dc.contributor.localIdA00232-
dc.contributor.localIdA04304-
dc.contributor.localIdA00277-
dc.contributor.localIdA00703-
dc.contributor.localIdA01244-
dc.contributor.localIdA01423-
dc.contributor.localIdA01654-
dc.contributor.localIdA02236-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA03363-
dc.contributor.localIdA03486-
dc.contributor.localIdA02773-
dc.contributor.localIdA00407-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25003873-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameKang, Ea Wha-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameKwon, Young Eun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKie, Jeong Hae-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.alternativeNameKim, Yung Ly-
dc.contributor.alternativeNameNam, Ki Heon-
dc.contributor.alternativeNamePark, Kyoung Sook-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameAn, Seong Yeong-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameChang, Tae Ik-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorKang, Ea Wha-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorKwon, Young Eun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKie, Jeong Hae-
dc.contributor.affiliatedAuthorKim, Yung Ly-
dc.contributor.affiliatedAuthorNam, Ki Heon-
dc.contributor.affiliatedAuthorPark, Kyoung Sook-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorAn, Seong Yeong-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorChang, Tae Ik-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.citation.volume9-
dc.citation.number7-
dc.citation.startPagee101935-
dc.identifier.bibliographicCitationPLOS ONE, Vol.9(7) : e101935, 2014-
dc.identifier.rimsid50241-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.