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Interleukin-6 induces the lineage commitment of bone marrow-derived mesenchymal multipotent cells through down-regulation of Sox2 by osteogenic transcription factors

DC FieldValueLanguage
dc.contributor.author박광환-
dc.contributor.author윤동석-
dc.contributor.author이경미-
dc.contributor.author이슬기-
dc.contributor.author이진우-
dc.contributor.author장연수-
dc.date.accessioned2015-01-06T16:55:57Z-
dc.date.available2015-01-06T16:55:57Z-
dc.date.issued2014-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99049-
dc.description.abstractBone marrow-derived mesenchymal stromal cells (BM-MSCs) are a heterogeneous population of cells that differ in size and morphology. BM-MSCs become committed to the osteogenic lineage as senescence approaches and lose multipotency. Nevertheless, little is known about the effects of cell-cell interaction between different populations on stemness loss and lineage commitment. The current study aimed to identify mechanisms by which cell-cell interactions between heterogeneous BM-MSCs affect stemness and lineage commitment of multipotent subpopulation. The lineage commitment of primitive multipotent cells was strongly induced in the presence of cytokines secreted by senescent-like cells in a cell culture insert system. Senescent-like cells secreted higher levels of interleukin-6 (IL-6) than primitive multipotent cells in a human cytokine array. IL-6 induced the lineage commitment and stemness loss in multipotent cells by decreasing Sox2 expression. Furthermore, we confirmed that IL-6 decreased the transcriptional activity of Sox2 through up-regulation of Runx2 and Dlx5. We suggest a mechanism by which IL-6 modulates the expression of Sox2, resulting in decreased multipotency and causing primitive multipotent cells to undergo osteogenic lineage commitment. This is the first study to identify mechanisms in which the cell-cell interactions between the different populations play important roles in the stemness loss and lineage commitment of multipotent populations.-Yoon, D. S., Kim, Y. H., Lee, S., Lee, K.-M., Park, K. H., Jang, Y., Lee, J. W. Interleukin-6 induces the lineage commitment of bone marrow-derived mesenchymal multipotent cells through down-regulation of Sox2 by osteogenic transcription factors.-
dc.description.statementOfResponsibilityopen-
dc.format.extent3273~3286-
dc.relation.isPartOfFASEB JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBone Marrow/metabolism*-
dc.subject.MESHCell Communication/genetics-
dc.subject.MESHCell Differentiation/genetics-
dc.subject.MESHCell Lineage/genetics*-
dc.subject.MESHCellular Senescence/genetics-
dc.subject.MESHCore Binding Factor Alpha 1 Subunit/genetics-
dc.subject.MESHCore Binding Factor Alpha 1 Subunit/metabolism-
dc.subject.MESHCytokines/genetics-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHDown-Regulation/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHHomeodomain Proteins/genetics-
dc.subject.MESHHomeodomain Proteins/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-6/genetics-
dc.subject.MESHInterleukin-6/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultipotent Stem Cells/metabolism*-
dc.subject.MESHOsteogenesis/genetics*-
dc.subject.MESHSOXB1 Transcription Factors/genetics*-
dc.subject.MESHSOXB1 Transcription Factors/metabolism-
dc.subject.MESHTranscription Factors/genetics-
dc.subject.MESHTranscription Factors/metabolism-
dc.subject.MESHTranscription, Genetic/genetics-
dc.subject.MESHUp-Regulation/genetics-
dc.subject.MESHYoung Adult-
dc.titleInterleukin-6 induces the lineage commitment of bone marrow-derived mesenchymal multipotent cells through down-regulation of Sox2 by osteogenic transcription factors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorDong Suk Yoon-
dc.contributor.googleauthorYun Hee Kim-
dc.contributor.googleauthorSeulgi Lee-
dc.contributor.googleauthorKyoung-Mi Lee-
dc.contributor.googleauthorKwang Hwan Park-
dc.contributor.googleauthorYeonsue Jang-
dc.contributor.googleauthorJin Woo Lee-
dc.identifier.doi10.1096/fj.13-248567-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02547-
dc.contributor.localIdA04619-
dc.contributor.localIdA03230-
dc.contributor.localIdA03449-
dc.contributor.localIdA02909-
dc.contributor.localIdA01437-
dc.relation.journalcodeJ00889-
dc.identifier.eissn1530-6860-
dc.identifier.pmid24719354-
dc.identifier.urlhttp://www.fasebj.org/content/28/7/3273.long-
dc.subject.keywordDlx5-
dc.subject.keywordRunx2-
dc.subject.keywordcell-cell interaction-
dc.subject.keywordheterogeneous population-
dc.subject.keywordstemness-
dc.contributor.alternativeNamePark, Kwang Hwan-
dc.contributor.alternativeNameYoon, Dong Suk-
dc.contributor.alternativeNameLee, Kyung Mi-
dc.contributor.alternativeNameLee, Seul Gi-
dc.contributor.alternativeNameLee, Jin Woo-
dc.contributor.alternativeNameJang, Yeon Sue-
dc.contributor.affiliatedAuthorYoon, Dong Suk-
dc.contributor.affiliatedAuthorLee, Kyoung Mi-
dc.contributor.affiliatedAuthorLee, Jin Woo-
dc.contributor.affiliatedAuthorJang, Yeon Sue-
dc.contributor.affiliatedAuthorLee, Seul Gi-
dc.contributor.affiliatedAuthorPark, Kwang Hwan-
dc.rights.accessRightsfree-
dc.citation.volume28-
dc.citation.number7-
dc.citation.startPage3273-
dc.citation.endPage3286-
dc.identifier.bibliographicCitationFASEB JOURNAL, Vol.28(7) : 3273-3286, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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