Cited 39 times in
Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer
DC Field | Value | Language |
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dc.contributor.author | 김혜연 | - |
dc.contributor.author | 노미령 | - |
dc.contributor.author | 양상화 | - |
dc.contributor.author | 이두영 | - |
dc.date.accessioned | 2015-01-06T16:55:24Z | - |
dc.date.available | 2015-01-06T16:55:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99031 | - |
dc.description.abstract | Glutathione peroxidase 3 (GPX3) is a member of the glutathione peroxidase family of selenoproteins and is one of the key defensive enzymes against oxidative damages to host cells. Downregulation of GPX3 due to its promoter hypermethylation has been documented in several different types of cancer, indicating that GPX3 functions as a possible tumor suppressor. In the present study, we showed that GPX3 is also significantly downregulated in cervical cancer tissues compared to normal cervical tissues by qRT-PCR analyses and immunohistostainings. GPX3 expression was significantly related to lymph node metastasis and prognosis in cervical cancer patients. Treatment of cervical cancer cells with 5-aza-2'-deoxycytidine restored the expression of GPX3 and methylation-specific PCR (MSP) confirmed the CpG methylation of the GPX3 gene. Our results indicate that promoter methylation is one of the major causes of GPX3 downregulation in cervical cancer and GPX3 could serve as a predictive biomarker for lymph node metastasis and prognosis of cervical cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2587~2592 | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Azacitidine/administration & dosage | - |
dc.subject.MESH | Azacitidine/analogs & derivatives | - |
dc.subject.MESH | CpG Islands/drug effects | - |
dc.subject.MESH | DNA Methylation/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.MESH | Glutathione Peroxidase/biosynthesis* | - |
dc.subject.MESH | Glutathione Peroxidase/genetics | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis/genetics* | - |
dc.subject.MESH | Lymphatic Metastasis/pathology | - |
dc.subject.MESH | Prognosis* | - |
dc.subject.MESH | Promoter Regions, Genetic/drug effects | - |
dc.subject.MESH | Uterine Cervical Neoplasms/genetics* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/pathology | - |
dc.title | Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Cancer Metastasis Research Center (암전이연구센터) | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | Zhenlong Zheng | - |
dc.contributor.googleauthor | Shen Yingji | - |
dc.contributor.googleauthor | Hyeyeon Kim | - |
dc.contributor.googleauthor | Renshun Jin | - |
dc.contributor.googleauthor | Li Renshu | - |
dc.contributor.googleauthor | Doo Young Lee | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Sanghwa Yang | - |
dc.identifier.doi | 10.3892/or.2014.3152 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A02288 | - |
dc.contributor.localId | A02746 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 24788695 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/31/6/2587 | - |
dc.subject.keyword | cervical cancer | - |
dc.subject.keyword | GPX3 | - |
dc.subject.keyword | downregulation | - |
dc.subject.keyword | lymph node metastasis | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.alternativeName | Yang, Sang Hwa | - |
dc.contributor.alternativeName | Lee, Doo Young | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | Yang, Sang Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Doo Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2587 | - |
dc.citation.endPage | 2592 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.31(6) : 2587-2592, 2014 | - |
dc.identifier.rimsid | 50220 | - |
dc.type.rims | ART | - |
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