1 489

Cited 103 times in

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients with Pancreatic Cancer

DC FieldValueLanguage
dc.contributor.author이정원-
dc.contributor.author이종두-
dc.contributor.author최혜진-
dc.contributor.author강창무-
dc.contributor.author송시영-
dc.contributor.author이우정-
dc.contributor.author이재훈-
dc.date.accessioned2015-01-06T16:55:17Z-
dc.date.available2015-01-06T16:55:17Z-
dc.date.issued2014-
dc.identifier.issn0161-5505-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99027-
dc.description.abstractIn this study, we aimed to assess the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured on 18F-FDG PET/CT in pancreatic cancer patients who underwent resection with curative intent. METHODS: Eighty-seven patients with pancreatic ductal adenocarcinoma who underwent 18F-FDG PET/CT and subsequent surgical resection with curative intent with (30 patients) or without (57 patients) neoadjuvant therapy were retrospectively enrolled. The maximum standardized uptake value (SUVmax), MTV, and TLG were measured on 18F-FDG PET/CT in all patients. The prognostic significances of PET/CT parameters and tumor factors for recurrence-free survival (RFS) and overall survival (OS) were evaluated by univariate and multivariate analyses. RESULTS: Of the 87 patients, 57 (64%) experienced recurrence during the follow-up period. The tumor size, pathologic T (pT) stage, SUVmax, MTV, and TLG were significant prognostic factors for both RFS and OS (P < 0.05) on univariate analyses, and the presence of lymph node metastasis showed significance only for predicting RFS (P < 0.05). On multivariate analyses, the tumor size, MTV, and TLG were independent prognostic factors for RFS, and pT stage, MTV, and TLG were independent prognostic factors for OS. For the 57 patients who did not undergo neoadjuvant treatment, MTV and TLG remained significant predictive factors for tumor recurrence, along with tumor size and SUVmax. CONCLUSION: MTV and TLG are independent prognostic factors for predicting RFS and OS in patients with pancreatic cancer. Thus, 18F-FDG PET/CT can provide useful prognostic information for patients undergoing resection of pancreatic cancer with curative intent irrespective of neoadjuvant treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent898~904-
dc.relation.isPartOfJOURNAL OF NUCLEAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18*-
dc.subject.MESHGlycolysis*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultimodal Imaging-
dc.subject.MESHPancreatic Neoplasms/diagnosis*-
dc.subject.MESHPancreatic Neoplasms/metabolism-
dc.subject.MESHPancreatic Neoplasms/pathology-
dc.subject.MESHPancreatic Neoplasms/surgery-
dc.subject.MESHPositron-Emission Tomography*-
dc.subject.MESHPreoperative Period*-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, X-Ray Computed*-
dc.subject.MESHTumor Burden*-
dc.titlePrognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients with Pancreatic Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJeong Won Lee-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorHye Jin Choi-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorJae-Hoon Lee-
dc.contributor.googleauthorJong Doo Lee-
dc.identifier.doi10.2967/jnumed.113.131847-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03117-
dc.contributor.localIdA03138-
dc.contributor.localIdA04219-
dc.contributor.localIdA00088-
dc.contributor.localIdA02035-
dc.contributor.localIdA02994-
dc.contributor.localIdA03093-
dc.relation.journalcodeJ01644-
dc.identifier.eissn1535-5667-
dc.identifier.pmid24711649-
dc.identifier.urlhttp://jnm.snmjournals.org/content/55/6/898.long-
dc.subject.keyword18F-FDG-
dc.subject.keywordPET-
dc.subject.keywordmetabolic tumor volume-
dc.subject.keywordpancreatic cancer-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameLee, Jeong Won-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameChoi, Hye Jin-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.affiliatedAuthorLee, Jeong Won-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorChoi, Hye Jin-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.rights.accessRightsfree-
dc.citation.volume55-
dc.citation.number6-
dc.citation.startPage898-
dc.citation.endPage904-
dc.identifier.bibliographicCitationJOURNAL OF NUCLEAR MEDICINE, Vol.55(6) : 898-904, 2014-
dc.identifier.rimsid50219-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.