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The role of S100A14 in epithelial ovarian tumors
DC Field | Value | Language |
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dc.contributor.author | 김선영 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 신하연 | - |
dc.contributor.author | 전경희 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2015-01-06T16:55:00Z | - |
dc.date.available | 2015-01-06T16:55:00Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99018 | - |
dc.description.abstract | S100A14 is an EF-hand calcium-binding protein that has been reported to be involved in the progression of many malignancies. However, its role in ovarian cancer has not yet been clarified. In this study, we investigated the significance of S100A14 expression in epithelial ovarian cancers (EOCs) as well as it's mechanism of action. On both RNA and protein levels, S100A14 was overexpressed in transformed cells. Immunohistochemical staining demonstrated that S100A14 expression was associated with advanced stage (P<0.001) and poor tumor grade (P<0.001). Moreover, S100A14 overexpression was an independent prognostic factor for overall survival (HR = 4.53, P = 0.029). We also investigated S100A14's functional role by employing lentiviral-mediated overexpression and knockdown in EOC cells. S100A14 overexpression promoted cell proliferation, tumorigenesis, migration, and invasion, whereas S100A14 knockdown inhibited these properties. TOV112D cells that overexpressed S100A14 also exhibited greater tumor growth potential in xenografted mice. S100A14 promoted such a malignant phenotype in EOC cells through the PI3K/Akt pathway. Taken together, our data indicate that S100A14 has a crucial role in EOC progression, and its overexpression is associated with poor prognosis. Further study of S100A14's molecular mechanisms may lead to the development of a novel therapeutic target for ovarian cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3482~3496 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers, Tumor/biosynthesis | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Calcium-Binding Proteins/biosynthesis* | - |
dc.subject.MESH | Calcium-Binding Proteins/genetics | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Movement/genetics | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Heterografts | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/genetics | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/metabolism* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/pathology | - |
dc.subject.MESH | Ovarian Neoplasms/genetics | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism* | - |
dc.subject.MESH | Ovarian Neoplasms/pathology | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases/metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | The role of S100A14 in epithelial ovarian tumors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Ha-Yeon Shin | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Jane Seon-Young Kim | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Eun Joo Chung | - |
dc.contributor.googleauthor | Kyung-Hee Chun | - |
dc.contributor.googleauthor | Stephen M. Hewitt | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00550 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A02169 | - |
dc.contributor.localId | A03501 | - |
dc.contributor.localId | A03921 | - |
dc.contributor.localId | A00595 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 24939856 | - |
dc.subject.keyword | Epithelial ovarian cancer | - |
dc.subject.keyword | tumor marker | - |
dc.subject.keyword | S100A14 | - |
dc.subject.keyword | shRNA | - |
dc.contributor.alternativeName | Kim, Seon Young | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Shin, Ha Yeon | - |
dc.contributor.alternativeName | Chun, Kyung Hee | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Seon Young | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Shin, Ha Yeon | - |
dc.contributor.affiliatedAuthor | Chun, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.citation.volume | 5 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3482 | - |
dc.citation.endPage | 3496 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.5(11) : 3482-3496, 2014 | - |
dc.identifier.rimsid | 50214 | - |
dc.type.rims | ART | - |
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