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Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group

Authors
 Hyojin Kim  ;  Hyo Sup Shim  ;  Lucia Kim  ;  Tae-Jung Kim  ;  Kun Young Kwon  ;  Geon Kook Lee  ;  Jin-Haeng Chung 
Citation
 Korean Journal of Pathology, Vol.48(1) : 1-9, 2014 
Journal Title
 Korean Journal of Pathology 
ISSN
 1738-1843 
Issue Date
2014
Abstract
Rearrangement of anaplastic lymphoma kinase (ALK) gene is the best predictor of response to crizotinib, an ALK tyrosine kinase inhibitor. However, the prevalence of the ALK fusion is low, so accurate patient identification is crucial for successful treatment using ALK inhibitors. Furthermore, most patients with lung cancer present with advanced-stage disease at the time of diagnosis, so it is important for pathologists to detect ALK-rearranged patients while effectively maximizing small biopsy or cytology specimens. In this review, we propose a guideline recommendation for ALK testing approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.
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DOI
10.4132/KoreanJPathol.2014.48.1.1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98858
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