Cited 18 times in
Detailed pathologic evaluation on endomyocardial biopsy provides long-term prognostic information in patients with acute myocarditis
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 윤종찬 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 이재석 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 지아영 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2015-01-06T16:50:00Z | - |
dc.date.available | 2015-01-06T16:50:00Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1054-8807 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98857 | - |
dc.description.abstract | BACKGROUND: The long-term prognosis of biopsy-proven myocarditis is not well known. We hypothesized that a detailed pathological examination of an endomyocardial biopsy (EMB) would reveal prognostic information in patients with acute myocarditis. METHODS: Fifty-four patients were diagnosed with acute myocarditis based on an EMB. Pathological diagnosis was categorized into lymphocytic dominant (29.6%), eosinophilic dominant (22.2%), and borderline myocarditis (48.1%). Masson's trichrome staining and further immunohistochemical staining for CD3, CD20, CD68, HLA-DR, TLR4, TLR8, enteroviral VP1, and caspase-3 expression were performed. The clinical outcomes were defined as all-cause and cardiovascular (CV) death. RESULTS: During the median 10.4 years of follow up (9.7±5.7 years), the overall all-cause mortality was 20.4% and the CV mortality was 14.8% in patients with acute myocarditis. Lymphocytic dominant myocarditis patients showed a poor clinical outcome when compared with eosinophilic dominant myocarditis patients for both all-cause (37.5% vs. 0%, p=0.015) and CV (31.2% vs. 0%, p=0.029) mortality. Among borderline myocarditis patients, the presence of fibrosis was linked with poor clinical outcomes in both all-cause (75.0% vs. 21.4%, p=0.045) and CV (100.0% vs. 25.0%, p=0.034) mortality. No significant associations between clinical outcome and all other immunohistochemical staining targets were observed. CONCLUSIONS: Detailed pathological evaluation on an EMB provides prognostic information in patients with acute myocarditis. EMB evaluation should be considered in patients with suspected myocarditis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 139~144 | - |
dc.relation.isPartOf | CARDIOVASCULAR PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Azo Compounds | - |
dc.subject.MESH | Biomarkers/analysis | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Coloring Agents | - |
dc.subject.MESH | Eosine Yellowish-(YS) | - |
dc.subject.MESH | Eosinophils/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lymphocytes/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methyl Green | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocarditis/metabolism | - |
dc.subject.MESH | Myocarditis/mortality | - |
dc.subject.MESH | Myocarditis/pathology* | - |
dc.subject.MESH | Myocardium/chemistry | - |
dc.subject.MESH | Myocardium/pathology* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Staining and Labeling/methods | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Detailed pathologic evaluation on endomyocardial biopsy provides long-term prognostic information in patients with acute myocarditis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Jae Seok Lee | - |
dc.contributor.googleauthor | Ah-Young Ji | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.identifier.doi | 10.1016/j.carpath.2014.01.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A02600 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A03966 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04388 | - |
dc.contributor.localId | A03072 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A02833 | - |
dc.relation.journalcode | J00462 | - |
dc.identifier.eissn | 1879-1336 | - |
dc.identifier.pmid | 24529879 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1054880714000052 | - |
dc.subject.keyword | Diagnosis | - |
dc.subject.keyword | Endomyocardial biopsy | - |
dc.subject.keyword | Histopathology | - |
dc.subject.keyword | Myocarditis | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.alternativeName | Youn, Jong Chan | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.alternativeName | Lee, Jae Seok | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Ji, Ah Young | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Nam Ki | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Youn, Jong Chan | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Ji, Ah Young | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Namki | - |
dc.contributor.affiliatedAuthor | Lee, Jae Seok | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 139 | - |
dc.citation.endPage | 144 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR PATHOLOGY, Vol.23(3) : 139-144, 2014 | - |
dc.identifier.rimsid | 38829 | - |
dc.type.rims | ART | - |
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