Cited 13 times in
C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상학 | - |
dc.contributor.author | 진태원 | - |
dc.contributor.author | 최은영 | - |
dc.contributor.author | 강석민 | - |
dc.contributor.author | 김수혁 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 이범섭 | - |
dc.date.accessioned | 2015-01-06T16:47:12Z | - |
dc.date.available | 2015-01-06T16:47:12Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98766 | - |
dc.description.abstract | C-reactive protein (CRP) is one of the most important biomarkers for arteriosclerosis and cardiovascular disease. Recent studies have shown that CRP affects cell cycle and inflammatory process in cardiac myocytes. Survivin is also involved in cardiac myocytes replication and apoptosis. Reduction of survivin expression is associated with less favorable cardiac remodeling in animal models. However, the effect of CRP on survivin expression and its cellular mechanism has not yet been studied. We demonstrated that treatment of CRP resulted in a significant decrease of survivin protein expression in a concentration-dependent manner in cardiac myocytes. The upstream signaling proteins of survivin, such as Akt, mTOR and p70S6K, were also downregulated by CRP treatment. In addition, CRP increased the protein and mRNA levels of PTEN. The siRNA transfection or specific inhibitor treatment for PTEN restored the CRP-induced downregulation of Akt/mTOR/p70S6K pathway and survivin protein expression. Moreover, pretreatment with a specific p53 inhibitor decreased the CRP-induced PTEN expression. ERK-specific inhibitor also blocked the p53 phosphorylation and PTEN expression induced by CRP. Our study provides a novel insight into CRP-induced downregulation of survivin protein expression in cardiac myocytes through mechanisms that involved in downregulation of Akt/mTOR/p70S6K pathway by expression of PTEN. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e98113 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | C-Reactive Protein/pharmacology* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Fluorescent Antibody Technique | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microtubule-Associated Proteins/genetics | - |
dc.subject.MESH | Microtubule-Associated Proteins/metabolism* | - |
dc.subject.MESH | Myocytes, Cardiac/cytology | - |
dc.subject.MESH | Myocytes, Cardiac/metabolism* | - |
dc.subject.MESH | PTEN Phosphohydrolase/genetics | - |
dc.subject.MESH | PTEN Phosphohydrolase/metabolism* | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/antagonists & inhibitors* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Ribosomal Protein S6 Kinases, 70-kDa/genetics | - |
dc.subject.MESH | Ribosomal Protein S6 Kinases, 70-kDa/metabolism | - |
dc.subject.MESH | TOR Serine-Threonine Kinases/antagonists & inhibitors* | - |
dc.subject.MESH | TOR Serine-Threonine Kinases/genetics | - |
dc.subject.MESH | TOR Serine-Threonine Kinases/metabolism | - |
dc.title | C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Beom Seob Lee | - |
dc.contributor.googleauthor | Soo Hyuk Kim | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Taewon Jin | - |
dc.contributor.googleauthor | Eun Young Choi | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Ji Hyung Chung | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.identifier.doi | 10.1371/journal.pone.0098113 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03990 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A00640 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02792 | - |
dc.contributor.localId | A04154 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A02395 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24866016 | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.alternativeName | Jin, Tae Won | - |
dc.contributor.alternativeName | Choi, Eun Young | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Kim, Soo Hyuk | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.alternativeName | Lee, Beom Seob | - |
dc.contributor.affiliatedAuthor | Jin, Tae Won | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Kim, Soo Hyuk | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Lee, Beom Seob | - |
dc.contributor.affiliatedAuthor | Choi, Eun Young | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.citation.volume | 9 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e98113 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(5) : e98113, 2014 | - |
dc.identifier.rimsid | 38595 | - |
dc.type.rims | ART | - |
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