7 379

Cited 37 times in

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2

Authors
 Ying Wu  ;  He Gao  ;  Huaixing Li  ;  Yasuharu Tabara  ;  Masahiro Nakatochi  ;  Yen-Feng Chiu  ;  Eun Jung Park  ;  Wanqing Wen  ;  Linda S. Adair  ;  Judith B. Borja  ;  Qiuyin Cai  ;  Yi-Cheng Chang  ;  Peng Chen  ;  Damien C. Croteau-Chonka  ;  Marie P. Fogarty  ;  Wei Gan  ;  Chih-Tsueng He  ;  Chao A. Hsiung  ;  Chii-Min Hwu  ;  Sahoko Ichihara  ;  Michiya Igase  ;  Jaeseong Jo  ;  Norihiro Kato  ;  Ryuichi Kawamoto  ;  Christophor W. Kuzawa  ;  Jeannette J.M. Lee  ;  Jianjun Liu  ;  Ling Lu  ;  Thomas W. Mcdade  ;  Haruhiko Osawa  ;  Wayne H-H. Sheu  ;  Yvonne Teo  ;  Swarooparani Vadlamudi  ;  Rob M. Van Dam  ;  Yiqin Wang  ;  Yong-Bing Xiang  ;  Ken Yamamoto  ;  Xingwang Ye  ;  Terri L. Young  ;  Wei Zheng  ;  Jingwen Zhu  ;  Xiao-Ou Shu  ;  Chol Shin  ;  Sun Ha Jee  ;  Lee-Ming Chuang  ;  Tetsuro Miki  ;  Mitsuhiro Yokota  ;  Xu Lin  ;  Karen L Mohlk  ;  E Shyong Tai 
Citation
 HUMAN MOLECULAR GENETICS, Vol.23(4) : 1108-1119, 2014 
Journal Title
 HUMAN MOLECULAR GENETICS 
ISSN
 0964-6906 
Issue Date
2014
MeSH
Adiponectin/blood* ; Asian Continental Ancestry Group ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/genetics* ; Cohort Studies ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Membrane Proteins/genetics* ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins/genetics* ; Receptor, Fibroblast Growth Factor, Type 2/genetics*
Keywords
obesity ; high density lipoprotein cholesterol ; triglycerides ; body mass index procedure ; conditioning (psychology) ; follow-up ; genome ; single nucleotide polymorphism ; genetics ; lipids ; adiponectin ; asian ; genome-wide association study ; fgfr2 gene ; paroxysmal extreme pain disorder
Abstract
Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10(-14)) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10(-7)). Of the adiponectin-associated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10(-165)), ADIPOQ (P = 1.8 × 10(-22)), PEPD (P = 3.6 × 10(-12)), CMIP (P = 2.1 × 10(-10)), ZNF664 (P = 2.3 × 10(-7)) and GPR109A (P = 7.4 × 10(-6)). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10(-7)). We further confirmed the independence of two pairs of closely located loci (<2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P = 3.3 × 10(-4)), high density lipoprotein cholesterol (HDL-C, P = 4.9 × 10(-4)) and body mass index (BMI)-adjusted waist-hip ratio (P = 9.8 × 10(-3)). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms.
Full Text
http://hmg.oxfordjournals.org/content/23/4/1108.long
DOI
10.1093/hmg/ddt488
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98761
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse