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Population-attributable causes of cancer in Korea: Obesity and physical inactivity

Authors
 Sohee Park  ;  Yeonju Kim  ;  Hai-Rim Shin  ;  Boram Lee  ;  Aesun Shin  ;  Kyu-Won Jung  ;  Sun Ha Jee  ;  Dong Hyun Kim  ;  Young Ho Yun  ;  Sue Kyung Park  ;  Mathieu Boniol  ;  Paolo Boffetta 
Citation
 PLOS ONE, Vol.9(4) : e90871, 2014 
Journal Title
 PLOS ONE 
Issue Date
2014
MeSH
Body Mass Index ; Body Weight ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Models, Statistical ; Motor Activity ; Neoplasms/complications* ; Neoplasms/epidemiology ; Neoplasms/etiology* ; Obesity/complications* ; Overweight ; Prevalence ; Prospective Studies ; Registries ; Republic of Korea/epidemiology ; Risk Factors ; Sedentary Lifestyle*
Abstract
BACKGROUND: Changes in lifestyle including obesity epidemic and reduced physical activity influenced greatly to increase the cancer burden in Korea. The purpose of the current study was to perform a systematic assessment of cancers attributable to obesity and physical inactivity in Korea. METHODOLOGY/PRINCIPAL FINDINGS: Gender- and cancer site-specific population-attributable fractions (PAF) were estimated using the prevalence of overweight and obesity in 1992-1995 from a large-scale prospective cohort study, the prevalence of low physical activity in 1989 from a Korean National Health Examination Survey, and pooled relative risk estimates from Korean epidemiological studies. The overall PAF was then estimated using 2009 national cancer incidence data from the Korea Central Cancer Registry. Excess body weight was responsible for 1,444 (1.5%) and 2,004 (2.2%) cancer cases among men and women, respectively, in 2009 in Korea. Among men, 6.8% of colorectal, 2.9% of pancreatic, and 16.0% of kidney cancer was attributable to excess body weight. In women, 6.6% of colorectal, 3.9% of pancreatic, 18.7% of kidney, 8.2% of postmenopausal breast, and 32.7% of endometrial cancer was attributable to excess body weight. Low leisure-time physical activity accounted for 8.8% of breast cancer, whereas the PAF for overall cancer was low (0.1% in men, 1.4% in women). Projections suggest that cancers attributable to obesity will increase by 40% in men and 16% in women by 2020. CONCLUSIONS/SIGNIFICANCE: With a significantly increasing overweight and physically inactive population, and increasing incidence of breast and colorectal cancers, Korea faces a large cancer burden attributable to these risk factors. Had the obese population of Korea remained stable, a large portion of obesity-related cancers could have been avoided. Efficient cancer prevention programs that aim to reduce obesity- and physical inactivity-related health problems are essential in Korea.
DOI
10.1371/journal.pone.0090871
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Park, So Hee(박소희) ORCID logo https://orcid.org/0000-0001-8513-5163
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98759
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