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White Matter Hyperintensities are associated with Amyloid Burden in APOE4 Non-Carriers

Authors
 Young Noh  ;  Sang Won Seo  ;  Seun Jeon  ;  Jong Min Lee  ;  Jung-Hyun Kim  ;  Geon Ha Kim  ;  Hanna Cho  ;  Cindy W. Yoon  ;  Hee Jin Kim  ;  Byoung Seok Ye  ;  Sung Tae Kim  ;  Yearn Seong Choe  ;  Kyung-Han Lee  ;  Jae Seung Kim  ;  Michael Ewers  ;  Michael W. Weiner  ;  Jae-Hong Lee  ;  David J. Werring  ;  Dae Ryong Kang  ;  Chang Soo Kim  ;  Duk L. Na 
Citation
 JOURNAL OF ALZHEIMERS DISEASE, Vol.40(4) : 877-886, 2014 
Journal Title
 JOURNAL OF ALZHEIMERS DISEASE 
ISSN
 1387-2877 
Issue Date
2014
MeSH
Aged ; Aged, 80 and over ; Amyloid beta-Peptides/metabolism* ; Aniline Compounds ; Apolipoprotein E4/genetics ; Brain/diagnostic imaging ; Brain/pathology ; Cognition Disorders/complications* ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/pathology ; Dementia, Vascular/complications* ; Dementia, Vascular/diagnostic imaging ; Dementia, Vascular/pathology ; Female ; Humans ; Leukoencephalopathies/diagnostic imaging ; Leukoencephalopathies/etiology* ; Leukoencephalopathies/pathology ; Male ; Neuropsychological Tests ; Positron-Emission Tomography ; Regression Analysis ; Retrospective Studies ; Statistics as Topic ; Thiazoles
Keywords
Alzheimer's disease ; amyloid burden ; apolipoprotein E4 ; cerebrovascular disease
Abstract
Previous preclinical studies have suggested a close relationship between cerebrovascular disease (CVD) and Alzheimer's disease. However, a direct correlation between CVD and amyloid burden has not yet been shown in humans. If there is a relationship between CVD and amyloid burden, it is possible that the apolipoprotein E4 (APOE4) genotype may have an effect on this relationship because APOE4 is a risk factor for the development of AD. We therefore evaluated the effects of APOE4 on the relationship between white matter hyperintensities (WMH), a marker of CVD, and amyloid burden, measured by 11C-Pittsburgh compound B (PiB) PET. We recruited 53 patients with subcortical vascular cognitive impairments, who had both WMH on MRI and amyloid deposition assessed by PiB PET. Twenty-two of these patients were APOE4 carriers (41.5%). In the APOE4 non-carriers, a significant positive correlation was shown between the volume of WMH and PiB retention (β = 7.0 × 10-3, p = 0.034) while no significant correlation was found in APOE4 carriers (β = -9.0 × 10-3, p = 0.085). Statistical parametric mapping analyses in APOE4 non-carriers showed that WMH were associated with PiB retention in the bilateral medial occipitotemporal gyrus, cuneus, and superior cerebellum. Our results suggested that WMH are correlated with amyloid burden especially in the posterior brain regions in APOE4 non-carriers. However, this correlation was not observed in APOE4 carriers, perhaps because in these subjects the influence of APOE4 overrides the effect of CVD.
Full Text
http://iospress.metapress.com/content/v455818724r96707/?genre=article&issn=1387-2877&volume=40&issue=4&spage=877
DOI
10.3233/JAD-130461
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Dae Ryong(강대용)
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98740
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