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Clinicopathologic features of solid variant papillary thyroid cancer

Authors
 Hojin Chang  ;  Seok Mo Kim  ;  Ki Won Chun  ;  Bup Woo Kim  ;  Yong Sang Lee  ;  Hang-Seok Chang  ;  Soon Won Hong  ;  Cheong Soo Park 
Citation
 ANZ JOURNAL OF SURGERY, Vol.84(5) : 380-382, 2014 
Journal Title
 ANZ JOURNAL OF SURGERY 
ISSN
 1445-1433 
Issue Date
2014
MeSH
Adult ; Aged ; Biopsy, Fine-Needle ; Carcinoma, Papillary/pathology* ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Middle Aged ; Thyroid Neoplasms/pathology
Keywords
aggressiveness ; cancer ; papillary ; solid ; variant
Abstract
BACKGROUND: Solid variant papillary thyroid cancer (SVPTC) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with SVPTC treated at our institution. METHODS: Of the 6052 patients with papillary thyroid cancer (PTC) evaluated at our institution between January 2008 and December 2011, 14 (0.23%) had SVPTC and were analysed retrospectively. RESULTS: Of the 14 patients with SVPTC, two were men and 12 were women, with a mean age of 48.2 years (range: 33-72 years). The mean follow-up period was 24 months (range: 8-36 months). All patients were assessed preoperatively by ultrasound-guided fine needle aspiration cytology (FNAC), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with SVPTC by preoperative FNAC, whereas 11 (78.6%) were diagnosed with PTC or suspected of having PTC. The mean tumour size was 1.02 ± 0.30 cm, with all tumours less than 2.0 cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1%) and the extrathyroidal invasion in seven (50.0%). The central lymph node metastases were found in five patients (35.7%), and the lateral lymph node metastasis in one (7.1%). No patient experienced tumour recurrence or distant metastasis during follow-up. CONCLUSIONS: Despite the small sample size and the short follow-up period, our results indicate that SVPTC may not be as aggressive a subtype as previously thought.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ans.12307/abstract
DOI
10.1111/ans.12307
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Bup Woo(김법우) ORCID logo https://orcid.org/0000-0002-1342-9055
Kim, Seok Mo(김석모) ORCID logo https://orcid.org/0000-0001-8070-0573
Park, Cheong Soo(박정수)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Chang, Ho Jin(장호진) ORCID logo https://orcid.org/0000-0002-8940-3484
Chun, Ki Won(전기원)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98735
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