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Lysyl-tRNA Synthetase (KRS) Expression in Gastric Carcinoma and Tumor-Associated Inflammation

 Baek-hui Kim  ;  Woon Yong Jung  ;  Hyunjoo Lee  ;  Youngran Kang  ;  You-Jin Jang  ;  Soon Won Hong  ;  Hyeong-jae Jeong  ;  Sun Och Yoon 
 ANNALS OF SURGICAL ONCOLOGY, Vol.21(6) : 2020-2027, 2014 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; CD4-Positive T-Lymphocytes/chemistry ; Carcinoma/chemistry* ; Carcinoma/pathology* ; Carcinoma/therapy ; Female ; Humans ; Inflammation/pathology* ; Ki-67 Antigen/analysis ; Lysine-tRNA Ligase/analysis* ; Macrophages/chemistry ; Male ; Middle Aged ; Monocytes/chemistry ; Neoplasm Invasiveness ; Neoplasm Staging ; Neutrophils/chemistry ; Stomach Neoplasms/chemistry* ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/therapy ; Survival Rate ; Tumor Necrosis Factor-alpha/analysis
Gastric Cancer ; Expression Status ; Digital Slide ; Independent Poor Prognostic Factor ; Standard Adjuvant Therapy
BACKGROUND: Lysyl-tRNA synthetase (KRS) is an aminoacyl-tRNA synthetase (ARS) that is essential for protein synthesis during ligation of specific amino acids to their cognate tRNAs. Aberrant expression of ARSs is associated with various human cancers. METHODS: Using immunohistochemical detection, the present study analyzed the clinical relevance of KRS expression in tumor cells and tumor-associated inflammatory cells (TAI) in 457 patients who underwent curative radical surgery and standard adjuvant therapy and who were observed on long-term follow-up. RESULTS: High expression of KRS in tumor cells (tumor-KRS(+)) was noted in 43.3 % (198 of 457) of cases. High expression of KRS in tumor-associated inflammatory cells (TAI-KRS(+)) including macrophages/monocytes, CD4-positive T cells, and/or neutrophils was observed in 37.2 % (170 of 457) of cases. Status of KRS in the tumor and TAI revealed an association with the known clinicopathological parameters for prognosis of gastric cancer. Tumor-KRS(+) status correlated to shorter overall survival, especially in stage III to IV cancers (P = 0.003), while TAI-KRS(+) status correlated significantly to longer overall survival in gastric cancer (P = 0.049). Cases with tumor-KRS(+) and TAI-KRS(-) status showed significantly reduced survival rates compared to those of other cases (P = 0.010), and status of tumor-KRS(+) and TAI-KRS(-) was revealed as an independently poor prognostic factor of overall survival (P = 0.001). CONCLUSIONS: KRS-related inflammation can be identified in a subset of gastric cancer. This may be a possible mechanism of immune surveillance against tumor progression. In addition, expression status of KRS in tumor and TAI may be an independent prognostic marker for gastric cancer patients.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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