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Lysyl-tRNA Synthetase (KRS) Expression in Gastric Carcinoma and Tumor-Associated Inflammation

Authors
 Baek-hui Kim  ;  Woon Yong Jung  ;  Hyunjoo Lee  ;  Youngran Kang  ;  You-Jin Jang  ;  Soon Won Hong  ;  Hyeong-jae Jeong  ;  Sun Och Yoon 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.21(6) : 2020-2027, 2014 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2014
MeSH
Adult ; Aged ; Aged, 80 and over ; CD4-Positive T-Lymphocytes/chemistry ; Carcinoma/chemistry* ; Carcinoma/pathology* ; Carcinoma/therapy ; Female ; Humans ; Inflammation/pathology* ; Ki-67 Antigen/analysis ; Lysine-tRNA Ligase/analysis* ; Macrophages/chemistry ; Male ; Middle Aged ; Monocytes/chemistry ; Neoplasm Invasiveness ; Neoplasm Staging ; Neutrophils/chemistry ; Stomach Neoplasms/chemistry* ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/therapy ; Survival Rate ; Tumor Necrosis Factor-alpha/analysis
Keywords
Gastric Cancer ; Expression Status ; Digital Slide ; Independent Poor Prognostic Factor ; Standard Adjuvant Therapy
Abstract
BACKGROUND: Lysyl-tRNA synthetase (KRS) is an aminoacyl-tRNA synthetase (ARS) that is essential for protein synthesis during ligation of specific amino acids to their cognate tRNAs. Aberrant expression of ARSs is associated with various human cancers. METHODS: Using immunohistochemical detection, the present study analyzed the clinical relevance of KRS expression in tumor cells and tumor-associated inflammatory cells (TAI) in 457 patients who underwent curative radical surgery and standard adjuvant therapy and who were observed on long-term follow-up. RESULTS: High expression of KRS in tumor cells (tumor-KRS(+)) was noted in 43.3 % (198 of 457) of cases. High expression of KRS in tumor-associated inflammatory cells (TAI-KRS(+)) including macrophages/monocytes, CD4-positive T cells, and/or neutrophils was observed in 37.2 % (170 of 457) of cases. Status of KRS in the tumor and TAI revealed an association with the known clinicopathological parameters for prognosis of gastric cancer. Tumor-KRS(+) status correlated to shorter overall survival, especially in stage III to IV cancers (P = 0.003), while TAI-KRS(+) status correlated significantly to longer overall survival in gastric cancer (P = 0.049). Cases with tumor-KRS(+) and TAI-KRS(-) status showed significantly reduced survival rates compared to those of other cases (P = 0.010), and status of tumor-KRS(+) and TAI-KRS(-) was revealed as an independently poor prognostic factor of overall survival (P = 0.001). CONCLUSIONS: KRS-related inflammation can be identified in a subset of gastric cancer. This may be a possible mechanism of immune surveillance against tumor progression. In addition, expression status of KRS in tumor and TAI may be an independent prognostic marker for gastric cancer patients.
Full Text
http://link.springer.com/article/10.1245%2Fs10434-014-3522-z
DOI
10.1245/s10434-014-3522-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98726
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