Cited 20 times in
Failure of Tooth Formation Mediated by miR-135a Overexpression via BMP Signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김은정 | - |
dc.contributor.author | 윤경식 | - |
dc.contributor.author | 이민정 | - |
dc.contributor.author | 이여문 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2015-01-06T16:45:45Z | - |
dc.date.available | 2015-01-06T16:45:45Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98719 | - |
dc.description.abstract | MicroRNAs (miRNAs) are known to regulate a variety of gene functions in many tissues and organs, but their expression and function in tooth development are not well-understood. A specific miRNA, miR-135a, was determined to be highly expressed at the bud stage. Interestingly, after the cap stage, miR-135a was expressed in the epithelium and mesenchyme but not in the inner enamel epithelium. To identify the relationship between miR-135a and its putative target genes, Bmpr-Ia and Bmpr-Ib, in early tooth development, miR-135a was ectopically overexpressed with a lentivirus. This overexpression resulted in the repression of Bmpr-Ia and Bmpr-Ib. Furthermore, miR-135a inhibited both Bmpr-Ia and Bmpr-Ib transcription. BMP2 proteins were expressed ectopically in tooth germs during the cap stage to determine the relationship between miR-135a and BMP signaling in early tooth development. When miR-135a was ectopically expressed, no tooth formation was observed after 4 wk of incubation in the kidney capsule. This study suggested that Bmp signaling, specifically Bmpr-Ia and Bmpr-Ib, regulates tooth formation via miR-135a. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 571~575 | - |
dc.relation.isPartOf | JOURNAL OF DENTAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/genetics | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/pharmacology | - |
dc.subject.MESH | Bone Morphogenetic Protein Receptors, Type I/genetics* | - |
dc.subject.MESH | Epithelium/metabolism | - |
dc.subject.MESH | Gene Expression Regulation/genetics* | - |
dc.subject.MESH | Genetic Vectors/genetics | - |
dc.subject.MESH | Lentivirus/genetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesoderm/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | MicroRNAs/antagonists & inhibitors | - |
dc.subject.MESH | MicroRNAs/genetics* | - |
dc.subject.MESH | Odontogenesis/genetics* | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Signal Transduction/genetics* | - |
dc.subject.MESH | Tooth Germ/drug effects | - |
dc.subject.MESH | Tooth Germ/metabolism | - |
dc.subject.MESH | Tooth Germ/transplantation | - |
dc.subject.MESH | Transcription, Genetic/genetics | - |
dc.subject.MESH | Transforming Growth Factor beta/pharmacology | - |
dc.subject.MESH | Substances | - |
dc.title | Failure of Tooth Formation Mediated by miR-135a Overexpression via BMP Signaling | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | E.J. Kim | - |
dc.contributor.googleauthor | M.J. Lee | - |
dc.contributor.googleauthor | L. Li | - |
dc.contributor.googleauthor | K.S. Yoon | - |
dc.contributor.googleauthor | K.S. Kim | - |
dc.contributor.googleauthor | H.S. Jung | - |
dc.identifier.doi | 10.1177/0022034514529303 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02540 | - |
dc.contributor.localId | A02949 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A00814 | - |
dc.contributor.localId | A02785 | - |
dc.relation.journalcode | J01367 | - |
dc.identifier.eissn | 1544-0591 | - |
dc.identifier.pmid | 24667771 | - |
dc.identifier.url | http://jdr.sagepub.com/content/93/6/571.long | - |
dc.subject.keyword | Bmp receptors | - |
dc.subject.keyword | lentivirus | - |
dc.subject.keyword | miRNA expression | - |
dc.subject.keyword | miRNA inhibitor | - |
dc.subject.keyword | microRNA | - |
dc.subject.keyword | tooth development | - |
dc.contributor.alternativeName | Kim, Eun Jung | - |
dc.contributor.alternativeName | Yoon, Kyung Sik | - |
dc.contributor.alternativeName | Lee, Min Jung | - |
dc.contributor.alternativeName | Li, Liwen | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Yoon, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Li, Liwen | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jung | - |
dc.contributor.affiliatedAuthor | Lee, Min Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 93 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 571 | - |
dc.citation.endPage | 575 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DENTAL RESEARCH, Vol.93(6) : 571-575, 2014 | - |
dc.identifier.rimsid | 38560 | - |
dc.type.rims | ART | - |
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