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마취 영역에서 약동, 약력 모형화

Other Titles
 Pharmacokinetic and pharmacodynamic modeling in anesthetic field 
 Anesthesia and Pain Medicine, Vol.9(2) : 77-86, 2014 
Journal Title
Anesthesia and Pain Medicine
Issue Date
Non-linear mixed effect model ; Pharmacokinetic ; pharmacodynamic model ; Population analysis ; Target controlled infusion.
Models are simplified descriptions of true biological processes. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is a mathematical description on the relationship between pharmacokinetics and pharmacodynamics. The PK/PD modeling allows estimation of PK/PD parameters and it can establish dose-concentration-response relationships which describe and predict the effect-time courses of a drug. PK/PD modeling has recently emerged as a major tool in clinical pharmacology in order to optimize drug uses by designing rational dosage forms. Population analysis is used to estimate the variability in the population and also to establish guidelines for the individualization of drug dosage regimen. Non-linear mixed effect model is the basis of population approach. This approach permits the simultaneous analysis for all the data of the studied population, by using either PK or PD models to describe the typical trends (population means) and individual profiles. The target controlled infusion system is based on the population PK models which describe the inter-individual PK variability by individualizing the PK parameters according to the patient’s covariate. The PK/PD modeling is highly useful for the development of drugs as well as for pharmacotherapy.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
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