880 677

Cited 0 times in

마취 영역에서 약동, 약력 모형화

Other Titles
 Pharmacokinetic and pharmacodynamic modeling in anesthetic field 
Authors
 한동우 
Citation
 Anesthesia and Pain Medicine, Vol.9(2) : 77-86, 2014 
Journal Title
Anesthesia and Pain Medicine
ISSN
 1975-5171 
Issue Date
2014
Keywords
Non-linear mixed effect model ; Pharmacokinetic ; pharmacodynamic model ; Population analysis ; Target controlled infusion.
Abstract
Models are simplified descriptions of true biological processes. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is a mathematical description on the relationship between pharmacokinetics and pharmacodynamics. The PK/PD modeling allows estimation of PK/PD parameters and it can establish dose-concentration-response relationships which describe and predict the effect-time courses of a drug. PK/PD modeling has recently emerged as a major tool in clinical pharmacology in order to optimize drug uses by designing rational dosage forms. Population analysis is used to estimate the variability in the population and also to establish guidelines for the individualization of drug dosage regimen. Non-linear mixed effect model is the basis of population approach. This approach permits the simultaneous analysis for all the data of the studied population, by using either PK or PD models to describe the typical trends (population means) and individual profiles. The target controlled infusion system is based on the population PK models which describe the inter-individual PK variability by individualizing the PK parameters according to the patient’s covariate. The PK/PD modeling is highly useful for the development of drugs as well as for pharmacotherapy.
Files in This Item:
T201401244.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98669
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links