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Shape Changes of the Basal Ganglia and Thalamus in Alzheimer’s Disease: A Three-Year Longitudinal Study

 Hanna Cho  ;  Jeong-Hun Kim  ;  Changsoo Kim  ;  Byoung Seok Ye  ;  Hee Jin Kim  ;  Cindy W. Yoon  ;  Young Noh  ;  Geon Ha Kim  ;  Yeo Jin Kim  ;  Jung-Hyun Kim  ;  Chang-Hun Kim  ;  Sue J. Kang  ;  Juhee Chin  ;  Sung Tae Kim  ;  Kyung-Han Lee  ;  Duk L. Na  ;  Joon-Kyung Seong  ;  Sang Won Seo 
 JOURNAL OF ALZHEIMERS DISEASE, Vol.40(2) : 285-295, 2014 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Alzheimer Disease/pathology* ; Analysis of Variance ; Basal Ganglia/pathology* ; Disease Progression ; Female ; Humans ; Imaging, Three-Dimensional ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Mental Status Schedule ; Neuropsychological Tests ; Thalamus/pathology*
Alzheimer's disease ; basal ganglia ; caudate nucleus ; globus pallidus ; putamen ; shape ; thalamus
Background: A large number of Alzheimer's disease (AD) studies have focused on medial temporal and cortical atrophy, while changes in the basal ganglia or thalamus have received less attention. Objective: The aim of this study was to investigate the existence of progressive topographical shape changes in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and thalamus concurrent with AD disease progression over three years. This study also examined whether declines in volumes of the basal ganglia or thalamus might be responsible for cognitive decline in patients with AD. Methods: Thirty-six patients with early stage AD and 14 normal control subjects were prospectively recruited for this study. All subjects were assessed with neuropsychological tests and MRI at baseline and Years 1 and 3. A longitudinal shape analysis of the basal ganglia and thalamus was performed by employing a boundary surface-based shape analysis method. Results: AD patients exhibited specific regional atrophy in the right caudate nucleus and the bilateral putamen at baseline, and as the disease progressed, regional atrophic changes in the left caudate nucleus were found to conform to a distinct topography after controlling the total brain volume. Volumetric decline of the caudate nucleus and putamen correlated with cognitive decline in frontal function after controlling for age, gender, education, follow-up years, and total brain volume changes. Conclusion: Our findings suggest that shape changes of the basal ganglia occurred regardless of whole brain atrophy as AD progressed and were also responsible for cognitive decline that was observed from the frontal function tests.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Hun(김정훈)
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
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