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Clinical characteristics of Graves' orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay

DC Field Value Language
dc.contributor.author윤진숙-
dc.contributor.author이은직-
dc.contributor.author신동엽-
dc.date.accessioned2015-01-06T16:44:00Z-
dc.date.available2015-01-06T16:44:00Z-
dc.date.issued2014-
dc.identifier.issn2234-2400-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98661-
dc.description.abstractOBJECTIVE: To investigate clinical characteristics of patients with Graves' orbitopathy (GO) who showed discrepancies between levels of thyroid-stimulating immunoglobulin (TSI) and thyrotropin-binding inhibitory immunoglobulin (TBII). DESIGN: Comparative case series. PATIENTS: A total of 317 patients with GO in whom Mc4-TSI and M22-TRAb (third-generation TBII) were measured simultaneously. Patients were divided into four groups according to TRAb levels as followings: Group 1, TBII and TSI < median value; Group 2, TBII ≥ median, TSI < median; Group 3, TBII < median, TSI ≥ median; Group 4, both TBII and TSI ≥ median. MEASUREMENT: Endocrine and ophthalmic clinical manifestations in each group. RESULTS: The median value of M22-TRAb was 6·11 IU/l and that of Mc4-TSI was 415·1 (SRR%). One hundred seventeen patients were classified as Group 1, 41 patients as Group 2, 41 patients as group 3 and 118 patients as group 4. Mean CAS was significantly higher in Groups 3 (2·2) and 4 (2·2) than in Groups 1 (1·6) and 2 (1·4; P = 0·001, ANOVA). Mean modified NOSPECS scores were significantly higher (P < 0·001, ANOVA) in Groups 3 (4·1) and 4 (4·1) than in Groups 1 (3·1) and 2 (2·3). The proportion of patients with hyperthyroidism was larger in Group 2 (85·4% [35/41 patients]) than in Group 3 (48·8% [20/41 patients]; P = 0·002). CONCLUSIONS: GO is more active and severe in patients with predominant Mc4-TSI than in patients with predominant M22-TRAb. Patients with hyperthyroidism were more likely to be included with patients with predominant M22-TRAb than with predominant Mc4-TSI.-
dc.description.statementOfResponsibilityopen-
dc.format.extent591~597-
dc.relation.isPartOfCLINICAL ENDOSCOPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHAutoantibodies/blood*-
dc.subject.MESHFemale-
dc.subject.MESHGraves Ophthalmopathy/blood*-
dc.subject.MESHGraves Ophthalmopathy/pathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulins, Thyroid-Stimulating/blood*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReceptors, Thyrotropin/immunology*-
dc.subject.MESHRetrospective Studies-
dc.titleClinical characteristics of Graves' orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorSun Young Jang-
dc.contributor.googleauthorDong Yeob Shin-
dc.contributor.googleauthorEun Jig Lee-
dc.contributor.googleauthorJin Sook Yoon-
dc.identifier.doi10.1111/cen.12318-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02611-
dc.contributor.localIdA03050-
dc.contributor.localIdA02093-
dc.relation.journalcodeJ00572-
dc.identifier.eissn2234-2443-
dc.identifier.pmid24033537-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/cen.12318/abstract-
dc.contributor.alternativeNameYoon, Jin Sook-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameShin, Dong Yeob-
dc.contributor.affiliatedAuthorYoon, Jin Sook-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorShin, Dong Yeob-
dc.rights.accessRightsfree-
dc.citation.volume80-
dc.citation.number4-
dc.citation.startPage591-
dc.citation.endPage597-
dc.identifier.bibliographicCitationCLINICAL ENDOSCOPY, Vol.80(4) : 591-597, 2014-
dc.identifier.rimsid38181-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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