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Red Cell Distribution Width as an Independent Predictor of Exercise Intolerance and Ventilatory Inefficiency in Patients with Chronic Heart Failure

DC Field Value Language
dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author윤종찬-
dc.contributor.author이상학-
dc.contributor.author최동훈-
dc.contributor.author홍남기-
dc.contributor.author홍성진-
dc.contributor.author이혜선-
dc.date.accessioned2015-01-06T16:43:49Z-
dc.date.available2015-01-06T16:43:49Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98655-
dc.description.abstractPURPOSE: Peak oxygen uptake (peak VO₂) and ventilatory inefficiency (VE/VCO₂ slope) have proven to be strong prognostic markers in patients with chronic heart failure (CHF). Recently increased red cell distribution width (RDW) has emerged as an additional predictor of poor outcome in CHF. We sought to evaluate the relationship between RDW and cardiopulmonary exercise test (CPET) parameters in CHF patients and healthy controls. MATERIALS AND METHODS: 85 ambulatory CHF patients (68 men, 54±10 years) and 107 healthy controls, who underwent a symptom-limited CPET on a treadmill according to the modified Bruce ramp protocol, were enrolled. CHF patients and healthy controls were divided into RDW tertile groups and laboratory, echocardiographic, and CPET results were analyzed. RESULTS: For patients with CHF, compared with patients in the lowest RDW tertile, those in the highest tertile had lower peak VO₂ (22 mL/kg/min vs. 28 mL/kg/min, p<0.001) and higher VE/VCO₂ slope (31 vs. 25, p=0.004). Multivariate regression analysis revealed RDW to be an independent predictor for peak VO₂ (β=-0.247, p=0.035) and VE/VCO₂ slope (β=0.366, p=0.004). The optimal cutoff value of RDW for predicting peak VO₂ ≤20 mL/kg/min and VE/VCO₂ slope ≥34 was 13.6% (sensitivity 53%, specificity 89%) and 13.4% (sensitivity 75%, specificity 82%), respectively. In contrast, for healthy controls, RDW was not related to both peak VO₂ and VE/VCO₂ slope. CONCLUSION: Higher RDW is independently related to peak VO₂ and VE/VCO₂ slope only in patients with CHF. RDW assessment, an inexpensive and simple method, might help predict functional capacity and ventilatory efficiency in these patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHErythrocyte Indices/physiology*-
dc.subject.MESHExercise Test-
dc.subject.MESHFemale-
dc.subject.MESHHeart Failure/physiopathology*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOxygen Consumption/physiology-
dc.subject.MESHRetrospective Studies-
dc.titleRed Cell Distribution Width as an Independent Predictor of Exercise Intolerance and Ventilatory Inefficiency in Patients with Chronic Heart Failure-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorSung-Jin Hong-
dc.contributor.googleauthorJong-Chan Youn-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorSeok-Min Kang-
dc.identifier.doi10.3349/ymj.2014.55.3.635-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA02600-
dc.contributor.localIdA04053-
dc.contributor.localIdA04388-
dc.contributor.localIdA04403-
dc.contributor.localIdA02395-
dc.contributor.localIdA03311-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24719129-
dc.subject.keywordCardiopulmonary exercise test-
dc.subject.keywordheart failure-
dc.subject.keywordred cell distribution width-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.alternativeNameYoun, Jong Chan-
dc.contributor.alternativeNameLee, Sang Hak-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.alternativeNameHong, Sung Jin-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorYoun, Jong Chan-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Namki-
dc.contributor.affiliatedAuthorHong, Sung Jin-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.citation.volume55-
dc.citation.number3-
dc.citation.startPage635-
dc.citation.endPage643-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(3) : 635-643, 2014-
dc.identifier.rimsid38176-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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