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Patterns and Biologic Features of p53 Mutation Types in Korean Breast Cancer Patients

Authors
 Hyung Won Kim  ;  Hak Min Lee  ;  Seung Hyun Hwang  ;  Sung Gwe Ahn  ;  Kyung-A Lee  ;  Joon Jeong 
Citation
 Journal of Breast Cancer, Vol.17(1) : 1-7, 2014 
Journal Title
 Journal of Breast Cancer 
ISSN
 1738-6756 
Issue Date
2014
Abstract
Purpose : The p53 gene is one of the most frequently mutated genes in breast cancer. We investigated the patterns and biologic features of p53 gene mutation and evaluated their clinical significance in Korean breast cancer patients. Methods : Patients who underwent p53 gene sequencing were included. Mutational analysis of exon 5 to exon 9 of the p53 gene was carried out using polymerase chain reaction-denaturing high performance liquid chromatography and direct sequencing. Results : A total of 497 patients were eligible for the present study and p53 gene mutations were detected in 71 cases (14.3%). Mutation of p53 was significantly associated with histologic grading (p<0.001), estrogen receptor and progesterone receptor status (p<0.001), HER2 status (p<0.001), Ki-67 (p=0.028), and tumor size (p=0.004). The most frequent location of p53 mutations was exon 7 and missense mutation was the most common type of mutation. Compared with patients without mutation, there was a statistically significant difference in relapse-free survival of patients with p53 gene mutation and missense mutation (p=0.020, p=0.006, respectively). Only p53 missense mutation was an independent prognostic factor for relapse-free survival in multivariate analysis, with an adjusted hazard ratio of 2.29 (95% confidence interval, 1.08-4.89, p=0.031). Conclusion : Mutation of the p53 gene was associated with more aggressive clinicopathologic characteristics and p53 missense mutation was an independent negative prognostic factor in Korean breast cancer patients.
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DOI
10.4048/jbc.2014.17.1.1
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
김형원(Kim, Hyung Won)
안성귀(Ahn, Sung Gwe) ORCID logo https://orcid.org/0000-0002-8778-9686
이경아(Lee, Kyung A) ORCID logo https://orcid.org/0000-0001-5320-6705
이학민(Lee, Hak Min)
정준(Jeong, Joon) ORCID logo https://orcid.org/0000-0003-0397-0005
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98567
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