Cited 240 times in
Remote Control of Gene Function by Local Translation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정호성 | - |
dc.date.accessioned | 2015-01-06T16:37:32Z | - |
dc.date.available | 2015-01-06T16:37:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98454 | - |
dc.description.abstract | The subcellular position of a protein is a key determinant of its function. Mounting evidence indicates that RNA localization, where specific mRNAs are transported subcellularly and subsequently translated in response to localized signals, is an evolutionarily conserved mechanism to control protein localization. On-site synthesis confers novel signaling properties to a protein and helps to maintain local proteome homeostasis. Local translation plays particularly important roles in distal neuronal compartments, and dysregulated RNA localization and translation cause defects in neuronal wiring and survival. Here, we discuss key findings in this area and possible implications of this adaptable and swift mechanism for spatial control of gene function. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 26~40 | - |
dc.relation.isPartOf | CELL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Nervous System Diseases/embryology | - |
dc.subject.MESH | Nervous System Diseases/metabolism | - |
dc.subject.MESH | Protein Biosynthesis* | - |
dc.subject.MESH | Proteins/chemistry | - |
dc.subject.MESH | Proteins/genetics* | - |
dc.subject.MESH | Proteins/metabolism* | - |
dc.subject.MESH | RNA Transport* | - |
dc.subject.MESH | RNA, Messenger/metabolism* | - |
dc.title | Remote Control of Gene Function by Local Translation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Hosung Jung | - |
dc.contributor.googleauthor | Christos G. Gkogkas | - |
dc.contributor.googleauthor | Nahum Sonenberg | - |
dc.contributor.googleauthor | Christine E. Holt | - |
dc.identifier.doi | 10.1016/j.cell.2014.03.005 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03786 | - |
dc.relation.journalcode | J00472 | - |
dc.identifier.eissn | 1097-4172 | - |
dc.identifier.pmid | 24679524 | - |
dc.contributor.alternativeName | Jung, Ho Sung | - |
dc.contributor.affiliatedAuthor | Jung, Ho Sung | - |
dc.citation.volume | 157 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 26 | - |
dc.citation.endPage | 40 | - |
dc.identifier.bibliographicCitation | CELL, Vol.157(1) : 26-40, 2014 | - |
dc.identifier.rimsid | 56613 | - |
dc.type.rims | ART | - |
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