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Co-infection with vaginal Ureaplasma urealyticum and Mycoplasma hominis increases adverse pregnancy outcomes in patients with preterm labor or preterm premature rupture of membranes

Authors
 Dong-Wook Kwak  ;  Han-Sung Hwang  ;  Ja-Young Kwon  ;  Yong-Won Park  ;  Young-Han Kim 
Citation
 Journal of Maternal-Fetal & Neonatal Medicine, Vol.27(4) : 333-337, 2014 
Journal Title
 Journal of Maternal-Fetal & Neonatal Medicine 
ISSN
 1476-7058 
Issue Date
2014
MeSH
Adult ; Chorioamnionitis/microbiology ; Coinfection/diagnosis ; Coinfection/epidemiology ; Female ; Fetal Membranes, Premature Rupture/microbiology* ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Mycoplasma Infections*/diagnosis ; Mycoplasma Infections*/epidemiology ; Mycoplasma hominis/isolation & purification* ; Obstetric Labor, Premature/microbiology* ; Patient Admission/statistics & numerical data ; Pregnancy ; Pregnancy Complications, Infectious*/diagnosis ; Pregnancy Complications, Infectious*/epidemiology ; Pregnancy Outcome ; Premature Birth/microbiology ; Prevalence ; Ureaplasma Infections*/diagnosis ; Ureaplasma Infections*/epidemiology ; Ureaplasma urealyticum/isolation & purification* ; Vagina/microbiology
Keywords
Antibiotic susceptibility ; Mycoplasma hominis ; PPROM ; preterm labor ; Ureaplasma urealyticum
Abstract
OBJECTIVE: The purpose of this study was to determine the prevalence of Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) in patients with preterm labor or preterm premature rupture of membranes (PPROM) and to determine the effect of these organisms on pregnancy outcomes based on the density of colonization. METHODS: The study group consisted of 184 women with preterm labor or PPROM. Vaginal cultures for UU and MH were performed for all patients at admission, and the placentas were histologically evaluated after delivery. RESULTS: The prevalence of positive vaginal fluid cultures for genital mycoplasma was 62.5% (112/179). This group included 99 patients carrying only UU and 13 carrying both organisms. No patients were found to carry only MH. Compared to patients only positive for UU, patients with both organisms showed significantly decreased gestational age at birth and birth weight, and significant increases in the incidences of preterm birth, NICU admissions and histologic chorioamnionitis. CONCLUSION: Vaginal MH tends to be detected with UU, and patients carrying both organisms simultaneously had more severe adverse pregnancy outcomes compared to patients in preterm labor or PPROM who were only positive for UU.
Full Text
http://informahealthcare.com/doi/abs/10.3109/14767058.2013.818124
DOI
10.3109/14767058.2013.818124
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Dong Wook(곽동욱)
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98357
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