Cited 4 times in
Predicting the pathologic response of locally advanced rectal cancer to neoadjuvant concurrent chemoradiation using enzyme linked immunosorbent assays (ELISAs) for biomarkers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금기창 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 이강영 | - |
dc.date.accessioned | 2015-01-06T16:32:09Z | - |
dc.date.available | 2015-01-06T16:32:09Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98289 | - |
dc.description.abstract | PURPOSE: To investigate the role of biomarkers including serum tissue inhibitor of metalloproteinases-1 (TIMP-1), urokinase plasminogen activator receptor, vascular endothelial growth factor, and epidermal growth factor receptor in predicting pathologic response to neoadjuvant chemoradiation (NACRT) for rectal cancer. METHODS: Between 2007 and 2009, 50 clinical TNM stage II or III patients were analyzed in this prospective study. Pre- and post-NACRT serum levels of biomarkers were assessed using ELISAs. The primary and secondary endpoints were pathologic complete response (pCR) and Mandard regression grade (MRG). RESULTS: The pCR was reported in 5 patients (10.0%). According to the MRG, fifteen patients (30.0%) were divided into group A (Grade I-II), the others in group B (Grade III-V). On univariate analysis, post-NACRT TIMP-1 showed notable significance with pCR (P = 0.092) and significant correlation with MRG group A (P = 0.003). Post-NACRT TIMP-1 ≤ 204.5 ng/mL as cut-off value by ROC curve was associated with more pCR and MRG group A patients (P = 0.016 and 0.002). Interval between NACRT and surgery was related to pCR with approached trend levels of significance (P = 0.05) and to MRG group A significantly on univariate analysis of clinical factors (P = 0.031). On multivariate analysis, post-NACRT TIMP-1 was not significantly related to pCR (P = 0.187), while it was significantly associated with MRG (P = 0.009). Among clinical responders, post-NACRT TIMP-1 level ≤ 204.5 ng/mL was significantly associated with pCR (P = 0.021) and MRG group A (P = 0.003). CONCLUSIONS: Post-NACRT serum TIMP-1 could be used as a predictive marker of pathologic response to NACRT in rectal cancer, even in patients with clinical response. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 399~409 | - |
dc.relation.isPartOf | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Biomarkers, Tumor/blood* | - |
dc.subject.MESH | Carcinoembryonic Antigen/blood | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant/adverse effects | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy/methods* | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/blood | - |
dc.subject.MESH | Receptors, Urokinase Plasminogen Activator/blood | - |
dc.subject.MESH | Rectal Neoplasms/blood | - |
dc.subject.MESH | Rectal Neoplasms/pathology* | - |
dc.subject.MESH | Rectal Neoplasms/therapy* | - |
dc.subject.MESH | Tissue Inhibitor of Metalloproteinase-1/blood* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/blood | - |
dc.title | Predicting the pathologic response of locally advanced rectal cancer to neoadjuvant concurrent chemoradiation using enzyme linked immunosorbent assays (ELISAs) for biomarkers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 10.1007/s00432-013-1578-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A04777 | - |
dc.relation.journalcode | J01283 | - |
dc.identifier.eissn | 1432-1335 | - |
dc.identifier.pmid | 24390211 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00432-013-1578-y | - |
dc.subject.keyword | Rectal neoplasms | - |
dc.subject.keyword | Predictive biological markers | - |
dc.subject.keyword | Neoadjuvant chemoradiotherapy | - |
dc.subject.keyword | Tissue inhibitor of metalloproteinase-1 | - |
dc.subject.keyword | Pathologic response | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Yoon, Hong In | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Yoon, Hong In | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 140 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 409 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.140(3) : 399-409, 2014 | - |
dc.identifier.rimsid | 51816 | - |
dc.type.rims | ART | - |
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