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Photothermal spectral-domain optical coherence reflectometry for direct measurement of hemoglobin concentration of erythrocytes

Authors
 Jinyeong Yim  ;  Hun Kim  ;  Suho Ryu  ;  Sungwook Song  ;  Hyun Ok Kim  ;  Kyung-A Hyun  ;  Hyo-Il Jung  ;  Chulmin Joo 
Citation
 BIOSENSORS & BIOELECTRONICS, Vol.57 : 59-64, 2014 
Journal Title
 BIOSENSORS & BIOELECTRONICS 
ISSN
 0956-5663 
Issue Date
2014
MeSH
Biosensing Techniques/instrumentation* ; Equipment Design ; Erythrocytes/chemistry* ; Hemoglobins/analysis* ; Humans ; Interferometry/instrumentation* ; Light ; Limit of Detection ; Refractometry/instrumentation* ; Temperature
Keywords
Erythrocytes ; Hemoglobin concentration ; Low coherence interferometry ; Photothermal effect ; Refractive index
Abstract
A novel optical detection method for hemoglobin concentration is described. The hemoglobin molecules consisting mainly of iron generate heat upon their absorption of light energy at 532 nm, which subsequently changes the refractive index of the blood. We exploit this photothermal effect to determine the hemoglobin concentration of erythrocytes without any preprocessing of blood. Highly sensitive measurement of refractive index alteration of blood samples is enabled by a spectral-domain low coherence reflectometric sensor with subnanometer-level optical path-length sensitivity. The performance and validity of the sensor are presented by comparing the measured results against the reference data acquired from an automatic hematology analyzer.
Full Text
http://www.sciencedirect.com/science/article/pii/S0956566314000700
DOI
10.1016/j.bios.2014.01.052
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98259
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