Cited 25 times in
Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김수정 | - |
dc.contributor.author | 김윤덕 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 엄주인 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 정회경 | - |
dc.contributor.author | 황도유 | - |
dc.date.accessioned | 2015-01-06T16:29:04Z | - |
dc.date.available | 2015-01-06T16:29:04Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98191 | - |
dc.description.abstract | Identification of biomarkers that predict responses to hypomethylating agents (HMAs) will allow optimal strategies for epigenetic therapy in myelodysplastic syndromes (MDS) to be established. Serum miR-21 was quantitatively measured in 58 MDS patients treated with HMAs and 14 healthy controls. Serum miR-192 was an internal control, and diagnostic performance was evaluated according to receiver operating characteristics (ROCs). ROC analysis indicated that serum miR-21 levels differentiated responders from non-responders with an area under the curve of 0.648 (95% confidence, 0.49 to 0.72). The baseline level of serum miR-21 was significantly lower in the responder group than in the non-responder group (P = 0.041). The overall response rate (ORR) of the high miR-21 group was significantly lower than that of the low miR-21 group (41.2 vs. 73.2%, P = 0.021). Progression-free survival (PFS) was significantly inferior in the high group versus the low group (14.0 vs. 44.5 months, P = 0.001). Multivariate analyses revealed that the initial serum miR-21 level (P = 0.001) and circulating blasts (P = 0.007) were prognostic factors for PFS. Serum miR-21 level was significantly associated with ORR and PFS in MDS patients treated with HMAs. Although validation with a large prospective study is required, serum miR-21 is a potential biomarker of epigenetic therapy in MDS patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e86933 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | DNA Methylation/genetics* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | MicroRNAs/blood* | - |
dc.subject.MESH | MicroRNAs/genetics | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Myelodysplastic Syndromes/blood* | - |
dc.subject.MESH | Myelodysplastic Syndromes/genetics* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reference Standards | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yundeok Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Yeo-Kyeoung Kim | - |
dc.contributor.googleauthor | Ju-In Eom | - |
dc.contributor.googleauthor | Hoi-Kyung Jeung | - |
dc.contributor.googleauthor | Soo Jeong Kim | - |
dc.contributor.googleauthor | Dohyu Hwang | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Hyeuong Joon Kim | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.identifier.doi | 10.1371/journal.pone.0086933 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A00790 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02338 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A03787 | - |
dc.contributor.localId | A04457 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24503739 | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Kim, Yun Deok | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Eom, Ju In | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Jeung, Hoi Kyung | - |
dc.contributor.alternativeName | Hwang, Doh Yu | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Yun Deok | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Eom, Ju In | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Jeung, Hoi Kyung | - |
dc.contributor.affiliatedAuthor | Hwang, Doh Yu | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e86933 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(2) : e86933, 2014 | - |
dc.identifier.rimsid | 50707 | - |
dc.type.rims | ART | - |
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