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Gender-specific pleiotropic bone–muscle relationship in the elderly from a nationwide survey (KNHANES IV)

Authors
 J. H. Huh  ;  M. K. Song  ;  K. H. Park  ;  K. J. Kim  ;  J. E. Kim  ;  Y. M. Rhee  ;  S. -K. Lim 
Citation
 Osteoporosis International, Vol.25(3) : 1053-1061, 2014 
Journal Title
 Osteoporosis International 
ISSN
 0937-941X 
Issue Date
2014
MeSH
Absorptiometry, Photon/methods ; Adult ; Aged ; Aged, 80 and over ; Aging/pathology ; Aging/physiology* ; Anthropometry/methods ; Bone Density/physiology* ; Female ; Femur Neck/physiopathology ; Hip Joint/physiopathology ; Humans ; Lumbar Vertebrae/physiopathology ; Male ; Middle Aged ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Nutrition Surveys ; Organ Size/physiology ; Osteoporosis/epidemiology ; Osteoporosis/physiopathology* ; Republic of Korea/epidemiology ; Sarcopenia/epidemiology ; Sarcopenia/pathology ; Sarcopenia/physiopathology* ; Sex Characteristics* ; Young Adult
Keywords
Bone-muscle relationship ; Gender specificity ; Osteoporosis ; Sarcopenia
Abstract
SUMMARY: The aim of this study was to examine the gender-specific association between sarcopenia and bone geometry/metabolic parameters. Low muscle mass was associated with greater deterioration of bone than in deterioration of glucose or lipid profiles. This bone-muscle relationship was more prominent in men than in women. INTRODUCTION: There are few studies that report on gender differences in the effects of low muscle mass on bone and metabolic parameters in elderly subjects. This study aimed to assess the gender-specific influence of muscle mass on bone and metabolic parameters. METHODS: A total of 2,264 participants (940 men and 1,324 women) whose age ranged from 65 to 92 years were analyzed using data from The Fourth Korea National Health and Nutrition Examination Surveys (2008-2009). We measured bone mineral density (BMD) and appendicular muscle mass using the dual-energy X-ray absorptiometry and also measured metabolic profiles. RESULTS: The age-related trend in bone and muscle coincided in men but not in women. Femoral neck (FN) and total hip (TH) BMD were highly correlated with muscle mass in both genders. However, in women, this correlation was not significant in the lumbar spine (LS). In addition, this positive correlation was stronger in the FN or TH than in the LS and was stronger in men than in women. Subjects with sarcopenia were at a higher risk for osteoporosis in the FN, TH, and LS in men, and in the TH and FN in women. The degree of association between muscle mass and metabolic profiles was relatively very weak. CONCLUSION: Bone-muscle relationship was more prominent in men than in women. The gender differences in bone-muscle relationship may be helpful for the development of gender-specific preventive strategies in the elderly, especially in men.
Full Text
http://link.springer.com/article/10.1007%2Fs00198-013-2531-2
DOI
10.1007/s00198-013-2531-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Jo Eun(김조은)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lim, Sung Kil(임승길)
Huh, Ji Hye(허지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98185
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