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The pathophysiological role of dendritic cell subsets in psoriasis

Authors
 Tae-Gyun Kim  ;  Dae Suk Kim  ;  Hyoung-Pyo Kim  ;  Min-Geol Lee 
Citation
 BMB REPORTS, Vol.47(2) : 60-68, 2014 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2014
MeSH
Animals ; Antigens, Surface/metabolism ; Dendritic Cells/immunology* ; Dendritic Cells/metabolism ; Humans ; Nitric Oxide Synthase Type II/metabolism ; Psoriasis/immunology ; Psoriasis/physiopathology* ; Tumor Necrosis Factor-alpha/metabolism
Keywords
Dendritic cells ; Psoriasis ; Skin
Abstract
Psoriasis is a chronic inflammatory disorder characterized by an erythematous scaly plaque of the skin and is occasionally accompanied by systemic complications. In the psoriatic lesions, an increased number of cytokine-producing dendritic cells and activated T cells are observed, which indicate that psoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging studies demonstrate novel roles for the dendritic cell subsets in the process of disease initiation and maintenance of psoriasis. In addition, recently discovered anti-psoriatic therapies, which specifically target inflammatory cytokines produced by lesional dendritic cells, bring much better clinical improvement compared to conventional treatments. These new therapies implicate the crucial importance of dendritic cells in psoriasis pathogenesis. This review will summarize and discuss the dendritic cell subsets of the human skin and their pathophysiological involvement in psoriasis based on mouse- and patient-oriented studies.
Files in This Item:
T201400385.pdf Download
DOI
10.5483/BMBRep.2014.47.2.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Suk(김대석)
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98178
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