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External validation of the RENAL nephrometry score nomogram for predicting high-grade renal cell carcinoma in solid, enhancing, and small renal masses

DC FieldValueLanguage
dc.contributor.author구교철-
dc.contributor.author나군호-
dc.contributor.author신태영-
dc.contributor.author유한나-
dc.contributor.author최영득-
dc.contributor.author함원식-
dc.contributor.author김종찬-
dc.date.accessioned2015-01-06T16:28:00Z-
dc.date.available2015-01-06T16:28:00Z-
dc.date.issued2014-
dc.identifier.issn0724-4983-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98157-
dc.description.abstractPURPOSE: To confirm predictive accuracies of the RENAL nephrometry score (RNS) nomogram for identifying malignancy and high-grade renal cell carcinoma (RCC) in an external cohort of small renal masses (SRMs). METHODS: A total of 1,129 patients who underwent extirpative renal surgery for solid and enhancing cT1 renal tumors between 2005 and 2012 at a single institution were included in the validation cohort. A single uro-radiologist utilized computed tomography image reconstruction to classify tumors according to the RNS. The area under the curve (AUC) and calibration plots were used to determine predictive accuracies of malignancy and high-grade models of the RNS nomogram. RESULTS: Malignant and high-grade tumors were identified in 1,012 (89.6%) and 389 (38.4%) patients with cT1 tumors, and in 658 (87.3%) and 215 (32.6%) patients with cT1a tumors, respectively. Predictive performances of the nomogram for malignancy and high-grade models revealed AUCs of 0.722 and 0.574 for cT1 tumors, and 0.727 and 0.495 for cT1a tumors, respectively. The predictive value of the malignancy model was comparable to that of the model-development cohort (AUC = 0.76); however, the predictive value of the high-grade model was inferior to that of the model-development cohort (AUC = 0.73). CONCLUSIONS: Unlike previous validation studies, we report inferior predictive performance of the RNS nomogram for discriminating high-grade RCC in solid and enhancing SRMs. This suggests that the RNS nomogram may be unreliable for preoperatively predicting high-grade RCC in SRMs, in which tumor size, the key determinant of high-grade RCC, is a limiting factor.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfWORLD JOURNAL OF UROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Renal Cell/diagnosis*-
dc.subject.MESHCarcinoma, Renal Cell/pathology-
dc.subject.MESHCarcinoma, Renal Cell/surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney/pathology*-
dc.subject.MESHKidney Neoplasms/diagnosis*-
dc.subject.MESHKidney Neoplasms/pathology-
dc.subject.MESHKidney Neoplasms/surgery-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNephrectomy-
dc.subject.MESHNomograms*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.titleExternal validation of the RENAL nephrometry score nomogram for predicting high-grade renal cell carcinoma in solid, enhancing, and small renal masses-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorHanna Yoo-
dc.contributor.googleauthorTae Young Shin-
dc.contributor.googleauthorJongchan Kim-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorWon Sik Ham-
dc.identifier.doi10.1007/s00345-013-1159-3-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00188-
dc.contributor.localIdA01227-
dc.contributor.localIdA02168-
dc.contributor.localIdA02529-
dc.contributor.localIdA04111-
dc.contributor.localIdA04337-
dc.relation.journalcodeJ02805-
dc.identifier.eissn1433-8726-
dc.identifier.pmid24013182-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00345-013-1159-3-
dc.subject.keywordCarcinoma-
dc.subject.keywordRenal cell-
dc.subject.keywordNomograms-
dc.subject.keywordValidation studies-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameShin, Tae Young-
dc.contributor.alternativeNameYoo, Han Na-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHam, Won Sik-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorShin, Tae Young-
dc.contributor.affiliatedAuthorYoo, Han Na-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHam, Won Sik-
dc.rights.accessRightsfree-
dc.citation.volume32-
dc.citation.number1-
dc.citation.startPage249-
dc.citation.endPage255-
dc.identifier.bibliographicCitationWORLD JOURNAL OF UROLOGY, Vol.32(1) : 249-255, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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