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Association between the poly(ADP-ribose)polymerase-1 gene polymorphism and advanced pelvic organ prolapse

Authors
 Ji Young Kim  ;  Eun Jae Kim  ;  Myung Jae Jeon  ;  Hoon Kim  ;  Yeo Jung Moon  ;  Sang Wook Bai 
Citation
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.21(2) : 177-81, 2014 
Journal Title
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
ISSN
 1072-3714 
Issue Date
2014
MeSH
Aged ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics* ; Genotype ; Humans ; Middle Aged ; Pelvic Organ Prolapse/genetics* ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases/genetics* ; Polymorphism, Genetic* ; Postmenopause ; Real-Time Polymerase Chain Reaction ; Republic of Korea ; Aged ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics* ; Genotype ; Humans ; Middle Aged ; Pelvic Organ Prolapse/genetics* ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases/genetics* ; Polymorphism, Genetic* ; Postmenopause ; Real-Time Polymerase Chain Reaction ; Republic of Korea
Keywords
Poly(ADP-ribose) polymerase-1 ; Oxidative stress ; Pelvic organ prolapse.
Abstract
OBJECTIVE: Apoptotic cell death, probably induced by oxidative stress, contributes to the development of pelvic organ prolapse. Because poly(ADP-ribose) polymerase-1 is an important mediator of cellular response to oxidative stress, genetic variations in the poly(ADP-ribose) polymerase-1 gene may play a role in the pathogenesis of pelvic organ prolapse. This study aimed to determine the association between advanced pelvic organ prolapse and Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene.
METHODS: A total of 340 women were enrolled in the study. The pelvic organ prolapse group consisted of 185 women with stage III or IV pelvic organ prolapse, whereas the control group consisted of 155 postmenopausal women with stage 0 or I pelvic organ prolapse who visited the hospital for treatment of benign gynecologic disease or routine gynecologic checkup. Genotyping of the poly(ADP-ribose) polymerase-1 Val762Ala polymorphism was performed by real-time polymerase chain reaction analysis using a TaqMan assay.
RESULTS: Genotype distribution in the pelvic organ prolapse group was different from that in the control group (P = 0.024). Furthermore, C-allele frequency was lower in the pelvic organ prolapse group than in the control group (P = 0.029). Women with the CC genotype had a 0.461-fold lower risk of developing advanced pelvic organ prolapse than women with the TT genotype (95% CI, 0.245-0.870; P = 0.017), and women with the C-allele had a 0.716-fold lower risk of developing advanced pelvic organ prolapse than women with the T-allele (95% CI, 0.527-0.973; P = 0.033).
CONCLUSIONS: These findings suggest that the poly(ADP-ribose) polymerase-1 Val762Ala polymorphism is associated with a decreased risk of advanced pelvic organ prolapse.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-201402000-00013&LSLINK=80&D=ovft
DOI
10.1097/GME.0b013e3182976f1f
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98085
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