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Inflammatory Cytokine and Osmolarity Changes in the Tears of Dry Eye Patients Treated with Topical 1% Methylprednisolone

DC Field Value Language
dc.contributor.author김세경-
dc.contributor.author김응권-
dc.contributor.author김태임-
dc.contributor.author이지환-
dc.date.accessioned2015-01-06T16:23:54Z-
dc.date.available2015-01-06T16:23:54Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98029-
dc.description.abstractPURPOSE: To evaluate changes in clinical outcomes, inflammatory cytokine levels, and tear osmolarity in the tears of patients with moderate to severe dry eye syndrome before and after the application of topical 1% methylprednisolone. MATERIALS AND METHODS: Thirty-two patients with moderate to severe dry eye unresponsive to previous aqueous enhancement therapy were enrolled. Five patients were lost to follow up, and twenty-seven patients were eligible for analysis. Patients were instructed to apply topical 1% methylprednisolone four times per day, as well as to continue applying their current therapy of preservative-free 0.1% sodium hyaluronate four times per day. Corneal and conjunctival staining scores, tear film breakup time (TFBUT), Schirmer test, and tear osmolarity were assessed at baseline, 4 weeks, and 8 weeks. Tear samples were collected at every visit for cytokine analysis. RESULTS: Corneal and conjunctival staining scores and TFBUT showed significant improvement at 4 (p<0.001, <0.001, <0.001 respectively) and 8 (p<0.001, <0.001, <0.001 respectively) weeks. Tear osmolarity decreased significantly at 8 weeks (p=0.008). Interleukin (IL)-1β, IL-8, and monocyte chemoattractant protein-1 were significantly decreased at 8 weeks compared with those at baseline (p=0.041, 0.001, 0.008 respectively). CONCLUSION: Short-term treatment with topical 1% methylprednisolone not only improved clinical outcomes, but also decreased tear osmolarity and cytokine levels. By measuring the changes in cytokine levels and tear osmolarity, we could objectively evaluate the anti-inflammatory effects of topical methylprednisolone applied in the treatment of patients with moderate to severe dry eye syndrome.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCytokines/metabolism*-
dc.subject.MESHDry Eye Syndromes/drug therapy*-
dc.subject.MESHDry Eye Syndromes/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMethylprednisolone/administration & dosage-
dc.subject.MESHMethylprednisolone/therapeutic use*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsmolar Concentration-
dc.subject.MESHProspective Studies-
dc.subject.MESHTears/chemistry*-
dc.subject.MESHTears/metabolism*-
dc.titleInflammatory Cytokine and Osmolarity Changes in the Tears of Dry Eye Patients Treated with Topical 1% Methylprednisolone-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorJi Hwan Lee-
dc.contributor.googleauthorKyung Min-
dc.contributor.googleauthorSe Kyung Kim-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorTae-im Kim-
dc.identifier.doi10.3349/ymj.2014.55.1.203-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00600-
dc.contributor.localIdA00831-
dc.contributor.localIdA01080-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24339308-
dc.subject.keywordDry eye syndrome-
dc.subject.keywordcytokines-
dc.subject.keywordmethylprednisolone-
dc.subject.keywordosmolar concentration-
dc.contributor.alternativeNameKim, Se Kyung-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameKim, Tae Im-
dc.contributor.affiliatedAuthorKim, Se Kyung-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Tae Im-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage203-
dc.citation.endPage208-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(1) : 203-208, 2014-
dc.identifier.rimsid54340-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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