178 305

Cited 0 times in

각막이식 거부반응 고위험군에서 전층각막이식술 후 저용량 사이클로스포린 투약에 따른 이식실패율

DC FieldValueLanguage
dc.contributor.author김응권-
dc.contributor.author이형근-
dc.date.accessioned2015-01-06T16:23:35Z-
dc.date.available2015-01-06T16:23:35Z-
dc.date.issued2014-
dc.identifier.issn0378-6471-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98020-
dc.description.abstractPurpose: To investigate the effect of low-dose systemic cyclosporine A (CsA) in preventing graft failure after high-risk penetrating keratoplasty (PKP). Methods: In this retrospective study, 36 eyes of 25 patients who underwent PKP were evaluated. At 24 months postoperatively, the failure rate in the CsA group (n = 19) was compared to the control group (n = 17). For subgroup analysis, the failure rate in the CsA group (n = 9) and control group (n = 9) was compared in patients who underwent a repeat PKP. The patients` side-effect profile was also collected. Results: The median follow-up in the CsA group was 32.8 months and 28.9 months in the control group. Graft failure occurred in 31.6% CsA patients and in 68.4% control patients (p = 0.311). In patients with repeat PKP, the failure rate in the CsA group was significantly lower than the control group (22.2% vs. 77.8%, p = 0.018). In one case (5.26%), CsA was discontinued due to gastroinstestinal discomfort. Conclusions: Low-dose CsA was not beneficial compared to conventional therapy in high-risk PKP patients. However, in the repeat PKP subgroup, the incidence of graft failure was lower with low-dose CsA than with conventional therapy. Although further study is necessary, adding low-dose CsA might be beneficial for repeat PKP patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent13~19-
dc.relation.isPartOfJOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title각막이식 거부반응 고위험군에서 전층각막이식술 후 저용량 사이클로스포린 투약에 따른 이식실패율-
dc.title.alternativeThe Efficacy of Low-Dose Systemic Cyclosporine for Graft Failure after Penetrating Keratoplasty in High-Risk Group-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthor조영주-
dc.contributor.googleauthor김응권-
dc.contributor.googleauthor이형근-
dc.identifier.doi10.3341/jkos.2014.55.1.13-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00831-
dc.contributor.localIdA03303-
dc.relation.journalcodeJ01838-
dc.identifier.eissn2092-9374-
dc.subject.keywordCorneal graft failure-
dc.subject.keywordCyclosporin A-
dc.subject.keywordPenetrating keratoplasty-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage13-
dc.citation.endPage19-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, Vol.55(1) : 13-19, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.