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각막이식 거부반응 고위험군에서 전층각막이식술 후 저용량 사이클로스포린 투약에 따른 이식실패율
DC Field | Value | Language |
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dc.contributor.author | 김응권 | - |
dc.contributor.author | 이형근 | - |
dc.date.accessioned | 2015-01-06T16:23:35Z | - |
dc.date.available | 2015-01-06T16:23:35Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0378-6471 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98020 | - |
dc.description.abstract | Purpose: To investigate the effect of low-dose systemic cyclosporine A (CsA) in preventing graft failure after high-risk penetrating keratoplasty (PKP). Methods: In this retrospective study, 36 eyes of 25 patients who underwent PKP were evaluated. At 24 months postoperatively, the failure rate in the CsA group (n = 19) was compared to the control group (n = 17). For subgroup analysis, the failure rate in the CsA group (n = 9) and control group (n = 9) was compared in patients who underwent a repeat PKP. The patients` side-effect profile was also collected. Results: The median follow-up in the CsA group was 32.8 months and 28.9 months in the control group. Graft failure occurred in 31.6% CsA patients and in 68.4% control patients (p = 0.311). In patients with repeat PKP, the failure rate in the CsA group was significantly lower than the control group (22.2% vs. 77.8%, p = 0.018). In one case (5.26%), CsA was discontinued due to gastroinstestinal discomfort. Conclusions: Low-dose CsA was not beneficial compared to conventional therapy in high-risk PKP patients. However, in the repeat PKP subgroup, the incidence of graft failure was lower with low-dose CsA than with conventional therapy. Although further study is necessary, adding low-dose CsA might be beneficial for repeat PKP patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 13~19 | - |
dc.relation.isPartOf | JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 각막이식 거부반응 고위험군에서 전층각막이식술 후 저용량 사이클로스포린 투약에 따른 이식실패율 | - |
dc.title.alternative | The Efficacy of Low-Dose Systemic Cyclosporine for Graft Failure after Penetrating Keratoplasty in High-Risk Group | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | 조영주 | - |
dc.contributor.googleauthor | 김응권 | - |
dc.contributor.googleauthor | 이형근 | - |
dc.identifier.doi | 10.3341/jkos.2014.55.1.13 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00831 | - |
dc.contributor.localId | A03303 | - |
dc.relation.journalcode | J01838 | - |
dc.identifier.eissn | 2092-9374 | - |
dc.subject.keyword | Corneal graft failure | - |
dc.subject.keyword | Cyclosporin A | - |
dc.subject.keyword | Penetrating keratoplasty | - |
dc.contributor.alternativeName | Kim, Eung Kweon | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.affiliatedAuthor | Kim, Eung Kweon | - |
dc.contributor.affiliatedAuthor | Lee, Hyung Keun | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 19 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, Vol.55(1) : 13-19, 2014 | - |
dc.identifier.rimsid | 54334 | - |
dc.type.rims | ART | - |
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