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Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Children With Allergic Rhinitis

Authors
 Yoon Hee Kim  ;  Hyun Bin Park  ;  Min Jung Kim  ;  Hwan Soo Kim  ;  Hee Seon Lee  ;  Yoon Ki Han  ;  Kyung Won Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 Allergy Asthma & Immunology Research, Vol.6(1) : 27-32, 2014 
Journal Title
 Allergy Asthma & Immunology Research 
ISSN
 2092-7355 
Issue Date
2014
Abstract
PURPOSE: Airway inflammation, bronchial hyper-responsiveness (BHR), and bronchodilator response (BDR) are representative characteristics of asthma. Because allergic rhinitis (AR) is a risk factor for asthma development, we evaluated these 3 characteristics in AR using measurement of fractional exhaled nitric oxide (FeNO), a methacholine challenge test (MCT), and impulse oscillometry (IOS). METHODS: This study included 112 children with asthma (asthma group), 196 children with AR (AR group), and 32 control subjects (control group). We compared pulmonary function parameters and FeNO levels among the 3 groups. The AR group was subdivided into 2 categories: the AR group with BHR and the AR group without, and again pulmonary function and FeNO levels were compared between the 2 subgroups. RESULTS: FeNO levels were more increased in the AR and asthma groups than in the control group; within the AR group, FeNO was higher in the AR group with BHR than in the AR group without. The BDR was more increased in the AR group than in the control group when percent changes in reactance at 5 Hz (Δ X5) and reactance area (Δ AX) were compared. In the AR group, however, there was no difference in Δ X5 and Δ AX between the AR group with BHR and the AR group without. CONCLUSIONS: Reversible airway obstruction on IOS and elevated FeNO levels were observed in children with AR. Because elevated FeNO levels can indicate airway inflammation and because chronic inflammation may lead to BHR, FeNO levels may be associated with BHR in AR. IOS can be a useful tool for detecting lower airway involvement of AR independent of BHR assessed in the MCT.
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T201400182.pdf Download
DOI
10.4168/aair.2014.6.1.27
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
김민정(Kim, Min Jung) ORCID logo https://orcid.org/0000-0002-5634-9709
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
박현빈(Park, Hyun Bin)
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
이희선(Lee, Hee Seon)
한윤기(Han, Yoon Ki)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98019
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