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Positive Maternal C-Reactive Protein Predicts Neonatal Sepsis

DC FieldValueLanguage
dc.contributor.author남궁란-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author이철-
dc.date.accessioned2015-01-06T16:22:16Z-
dc.date.available2015-01-06T16:22:16Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97982-
dc.description.abstractPURPOSE: To evaluate the diagnostic performance of maternal inflammatory marker: C-reactive protein (CRP) in predicting early onset neonatal sepsis (that occurring within 72 hours after birth). MATERIALS AND METHODS: 126 low birth weight newborns (gestation 32±3.2 wk, birth weight 1887±623 g) and their mothers were included. Neonates were divided into sepsis group (n=51) including both proven (positive blood culture) and suspected (negative blood culture but with more than 3 abnormal clinical signs), and controls (n=75). Mothers were subgrouped into CRP positive ≥1.22 mg/dL (n=48) and CRP negative <1.22 mg/dL (n=78) group, determined by Receiver Operating Characteristic curves, and odds ratio was calculated for neonatal sepsis according to maternal condition. RESULTS: Maternal CRP was significantly higher in neonatal sepsis group than in control (3.55±2.69 vs. 0.48±0.31 mg/dL, p=0.0001). Maternal CRP (cutoff value >1.22 mg/dL) had sensitivity 71% and specificity 84% for predicting neonatal sepsis. Maternal CRP positive group had more neonatal sepsis than CRP negative group (71% vs. 29%, p<0.001). Odds ratio of neonatal sepsis in maternal CRP positive group versus CRP negative group was 10.68 (95% confidence interval: 4.313-26.428, p<0.001). CONCLUSION: The risk of early onset neonatal sepsis significantly increased in the case of positive maternal CRP (≥1.22 mg/dL). In newborn of CRP positive mother, the clinician may be alerted to earlier evaluation for possible neonatal infection prior to development of sepsis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent113~117-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHC-Reactive Protein/metabolism*-
dc.subject.MESHChorioamnionitis/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHMale-
dc.subject.MESHMothers-
dc.subject.MESHPregnancy-
dc.subject.MESHSepsis/diagnosis-
dc.subject.MESHSepsis/metabolism*-
dc.titlePositive Maternal C-Reactive Protein Predicts Neonatal Sepsis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJi Hyun Jeon-
dc.contributor.googleauthorRan Namgung-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorKoo In Park-
dc.contributor.googleauthorChul Lee-
dc.identifier.doi10.3349/ymj.2014.55.1.113-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01241-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA03253-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24339295-
dc.subject.keywordNeonatal sepsis-
dc.subject.keywordchorioamnionitis-
dc.subject.keywordmaternal C-reacitve protein-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameLee, Chul-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorLee, Chul-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage113-
dc.citation.endPage117-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(1) : 113-117, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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