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The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study
DC Field | Value | Language |
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dc.contributor.author | 정진룡 | - |
dc.contributor.author | 조성빈 | - |
dc.contributor.author | 김도영 | - |
dc.date.accessioned | 2015-01-06T16:20:47Z | - |
dc.date.available | 2015-01-06T16:20:47Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0926-9959 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97937 | - |
dc.description.abstract | BACKGROUND: Mobilized CD34+ cells in peripheral blood have angiogenic potential, which is an important factor in active hair growth. In addition, activated autologous platelet-rich plasma (PRP) has been reported to induce the proliferation of dermal papilla cells. OBJECTIVES: To investigate the clinical efficacy of interfollicular injection of CD34+ cell-containing PRP preparation for pattern hair loss. PATIENTS AND METHODS: CD34+ cell-containing PRP preparation was injected on the scalps of 13 patients with pattern hair loss, and 13 patients were treated with interfollicular placental extract injection as a control. The numbers of platelets in PRP were microscopically counted and CD34+ cells were evaluated with flow cytometry. RESULTS: Three months after the first treatment, the patients presented clinical improvement in the mean number of hairs, 20.5 ± 17.0% (P < 0.0001), mean hair thickness, 31.3 ± 30.1% (P < 0.0001), and mean two-point score, 84.4 ± 51.7% (P < 0.0001) compared with baseline values. At 6 months, the patients presented clinical improvement in mean hair count, 29.2 ± 17.8% (P < 0.0001), mean hair thickness, 46.4 ± 37.5% (P < 0.0001), and mean two-point score, 121.3 ± 66.8% (P < 0.0001) compared with baseline. The MIXED procedure revealed that CD34+ cell-containing PRP treatment presented a higher degree of improvement than placental extract treatment in hair thickness (P = 0.027) and overall clinical improvement (P = 0.023). CONCLUSION: Our data suggest that the interfollicular injection of autologous CD34+ cell-containing PRP preparation has a positive therapeutic effect on male and female pattern hair loss without remarkable major side-effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 72~79 | - |
dc.relation.isPartOf | JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alopecia/therapy* | - |
dc.subject.MESH | Antigens, CD34/immunology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Platelet-Rich Plasma* | - |
dc.title | The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | J.-S. Kang | - |
dc.contributor.googleauthor | Z. Zheng | - |
dc.contributor.googleauthor | M.J. Choi | - |
dc.contributor.googleauthor | S.-H. Lee | - |
dc.contributor.googleauthor | D.-Y. Kim | - |
dc.contributor.googleauthor | S.B. Cho | - |
dc.identifier.doi | 10.1111/jdv.12062 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03741 | - |
dc.contributor.localId | A03832 | - |
dc.contributor.localId | A00384 | - |
dc.relation.journalcode | J01783 | - |
dc.identifier.eissn | 1468-3083 | - |
dc.identifier.pmid | 23279091 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jdv.12062/abstract | - |
dc.contributor.alternativeName | Zheng, Zhen Long | - |
dc.contributor.alternativeName | Cho, Sung Bin | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Zheng, Zhen Long | - |
dc.contributor.affiliatedAuthor | Cho, Sung Bin | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 72 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, Vol.28(1) : 72-79, 2014 | - |
dc.identifier.rimsid | 53440 | - |
dc.type.rims | ART | - |
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