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Evaluation of humoral immune response to nosocomial pathogen and functional status in elderly patients with sepsis.

DC FieldValueLanguage
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author용동은-
dc.contributor.author윤상선-
dc.contributor.author정수진-
dc.contributor.author한상훈-
dc.date.accessioned2015-01-06T16:20:22Z-
dc.date.available2015-01-06T16:20:22Z-
dc.date.issued2014-
dc.identifier.issn0167-4943-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97925-
dc.description.abstractThe clinical significance of humoral immune response to nosocomial pathogens and functional status in elderly patients with sepsis is not clear. We evaluated the humoral immune to nosocomial pathogens and the effect of functional dependencies on clinical outcomes among elderly patients with sepsis. This study prospectively enrolled patients aged ≥65 years with sepsis from September 2011 to May 2012 at a 2000-bed university hospital. The data including CD4 and CD8 T-cell count, functional status by measuring basic activities of daily living (ADL) and instrumental activities of daily living (IADL) were collected for all patients. In addition, the collected blood samples were analyzed for serum antibody levels against nosocomial pathogens using an ELISA. During the study period, 72 patients (38 males) treated with sepsis were enrolled. The all-cause in-hospital mortality rate was 16.7% (12/72). The mean CD4/CD8 T-cell ratio was significantly lower in nonsurvivors than in survivors (1.08 ± 0.72 vs. 1.93 ± 1.42, P = 0.003). Serum antibody titers to Acinetobacter baumannii, Klebsiella pneumonia, Stenotrophomonas maltophilia, and Enterococcus faecalis were statistically higher in nonsurvivors than in survivors. On multivariate analysis, the IADL score was independently predictive of mortality in elderly patients with sepsis (odds ratio 1.410, 95% confidence interval 1.007–1.975, P = 0.046). These results suggest that IADL scores could be used as predictors to identify elderly patients with a poor prognosis of nosocomial infections.-
dc.description.statementOfResponsibilityopen-
dc.format.extent10~14-
dc.relation.isPartOfARCHIVES OF GERONTOLOGY AND GERIATRICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActivities of Daily Living*-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Bacterial/blood-
dc.subject.MESHAntibodies, Bacterial/immunology*-
dc.subject.MESHCD4-CD8 Ratio-
dc.subject.MESHCause of Death/trends-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHCross Infection/immunology*-
dc.subject.MESHCross Infection/mortality-
dc.subject.MESHCross Infection/physiopathology-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHospital Mortality/trends-
dc.subject.MESHHumans-
dc.subject.MESHImmunity, Humoral*-
dc.subject.MESHMale-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSepsis/immunology*-
dc.subject.MESHSepsis/mortality-
dc.subject.MESHSepsis/physiopathology-
dc.subject.MESHT-Lymphocytes/immunology*-
dc.subject.MESHTime Factors-
dc.titleEvaluation of humoral immune response to nosocomial pathogen and functional status in elderly patients with sepsis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSang Sun Yoon-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorDong Eun Yong-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1016/j.archger.2013.07.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA02423-
dc.contributor.localIdA02558-
dc.contributor.localIdA03638-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ00219-
dc.identifier.eissn1872-6976-
dc.identifier.pmid23998496-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167494313001088-
dc.subject.keywordElderly patients-
dc.subject.keywordFunctional status-
dc.subject.keywordHumoral immunity-
dc.subject.keywordRisk factors-
dc.subject.keywordSepsis-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameYoon, Sang Sun-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorYoon, Sang Sun-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.rights.accessRightsfree-
dc.citation.volume58-
dc.citation.number1-
dc.citation.startPage10-
dc.citation.endPage14-
dc.identifier.bibliographicCitationARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.58(1) : 10-14, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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