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염화비닐 노출 근로자의 요중 Malondialdehyde 농도 수준
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김광숙 | - |
dc.contributor.author | 김치년 | - |
dc.contributor.author | 노재훈 | - |
dc.contributor.author | 원종욱 | - |
dc.date.accessioned | 2014-12-21T17:35:54Z | - |
dc.date.available | 2014-12-21T17:35:54Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1226-4326 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97894 | - |
dc.description.abstract | The aim of this study was to investigate whether the exposure to vinyl chloride monomer(VCM) induces lipid peroxidation in workers by evaluating the concentration of malondialdehyde(MDA) in the urine in order to assess worker`s oxidative stress due to exposure of vinyl chloride monomer. The subjects investigated in the study were divided into the experimental group; 18 workers exposed to VCM, and the control group; 19 workers unexposed to VCM. A gas chromatography/pulsed flame photometric detector(GC/PFPD) was utilized to analyze thiodiglycolic acid(TDGA), which was methylated with trimethylsilyldiazomethane (2.0M in diethyl ether) in urine and the urinary MDA, the product of lipid peroxidation, was determined by high-performance liquid chromatography/ultraviolet-visible detector after derivatized with 2,4-dinitrophenylhydrazine(DNPH). The concentrations of urinary TDGA in controls and VCM exposure workers were 0.13(2.01)mg/g Cr. GM(GSD) and 0.35(1.96)mg/gCr. GM(GSD), respectively. The concentrations of urinary MDA were 0.12(2.21)μmol/gCr. GM(GSD) in controls and 1.35(1.79)μmol/gCr. GM(GSD) in VCM exposure workers. As a result of simple regressions analysis between urinary concentration of TDGA and MDA in VCM exposure workers, it was found that the R2 value was 0.261 (p=0.03) and the drinking and smoking did not affect their level. In conclusion, the workers exposed to VCM have a potentially to suffered by oxidative stress due to VCM exposure and the urinary MDA can be applicable to the marker of effect to assess the level of worker`s VCM exposure. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 81~88 | - |
dc.relation.isPartOf | Journal of Korean Society of Occupational and Environmental Hygiene (한국산업위생학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 염화비닐 노출 근로자의 요중 Malondialdehyde 농도 수준 | - |
dc.title.alternative | The level of urinary malondialdehyde concentrations in vinyl chloride monomer exposure workers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | 김현수 | - |
dc.contributor.googleauthor | 김치년 | - |
dc.contributor.googleauthor | 노재훈 | - |
dc.contributor.googleauthor | 안미현 | - |
dc.contributor.googleauthor | 김광숙 | - |
dc.contributor.googleauthor | 박준호 | - |
dc.contributor.googleauthor | 원종욱 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00314 | - |
dc.contributor.localId | A01064 | - |
dc.contributor.localId | A01294 | - |
dc.contributor.localId | A02442 | - |
dc.relation.journalcode | J03170 | - |
dc.identifier.url | http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2769208 | - |
dc.contributor.alternativeName | Kim, Gwang Suk | - |
dc.contributor.alternativeName | Kim, Chi Nyon | - |
dc.contributor.alternativeName | Roh, Jae Hoon | - |
dc.contributor.alternativeName | Won, Jong Uk | - |
dc.contributor.affiliatedAuthor | Kim, Gwang Suk | - |
dc.contributor.affiliatedAuthor | Kim, Chi Nyon | - |
dc.contributor.affiliatedAuthor | Roh, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Won, Jong Uk | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 88 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Occupational and Environmental Hygiene (한국산업위생학회지), Vol.17(2) : 81-88, 2007 | - |
dc.identifier.rimsid | 44929 | - |
dc.type.rims | ART | - |
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