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돼지에서 단일 전신 방사선 조사 용량에 따른 혈액변화 관찰

Other Titles
 Effects of Single Total Body Irradiation (TBI) on the Peripheral Blood of Piglets 
 이재훈  ;  강은희  ;  김휘율  ;  최치봉  ;  장원경  ;  박진기  ;  안정용  ;  신현수  ;  김재환  ;  김동구  ;  정다정 
 Journal of Life Science (생명과학회지), Vol.17(12) : 1654-1659, 2007 
Journal Title
 Journal of Life Science (생명과학회지) 
Issue Date
We examined total body irradiation (TBI)-induced effects by complete blood count (CBC) and fluorescence-activated cell sorter analysis (FACS) in the piglet following radiation irritation. A CBC included red blood cell count, white blood cell count, and platelet cell count. Four piglets were examined in this study and each piglet was divided by irradiation dose, two piglets with 4 Gy, two with 6 Gy, one with 8 Gy. All piglets showed leukopenia, thrombocytopenia after irradiation. In 6 and 8 Gy group, three piglets showed severe hemostatic disorder and gastrointestinal disorder suchas diarrhea and anorexia, and they died between 10 and 15 days after radiation irritation. In 4 Gy, two piglets showed no clinical sign after radiation injury, but persistent leukopenia was shown in blood examination. We suggest that a single TBI dose less than 6 Gy is adequate for conditioning piglet for bone marrow transplantation.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Jung Yong(안정용)
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