Cited 0 times in
Protein transduction domain을 이용한 recombinant human bone morphogenetic protein-2의 골재생효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창성 | - |
dc.contributor.author | 김형준 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 조규성 | - |
dc.date.accessioned | 2014-12-21T17:33:02Z | - |
dc.date.available | 2014-12-21T17:33:02Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0250-3352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97802 | - |
dc.description.abstract | Bone morphogenetic proteins(BMPs) are regarded as members of the transforming growth $factor-{\beta}$ superfamily with characteristic features in their amino acid sequences. A number of studies have demonstrated the biologic activities of BMPs, which include the induction of cartilage and bone formation. Recently there was a attempt to overcome a limitation of mass production, and economical efficieny of rh-BMPs. The method producing PTD by using bacteria have advantages of acquiry a mass of proteins. Hences, a new treatment which deliver protein employed by protein transduction domain(PTD) has been tried. The purpose of this study was to evaluate the bone regenerative effect of TATBMP-2 and TAT-HA2-BMP-2 employed by PTD from HlV-1 TAT protein for protein translocation in the rat calvarial model. An 8mm calvarial, critical size osteotomy defect was created in each of 32 male Spraque-Dawley rats(weight $250{\sim}300g$). The animals were divided into 4 groups of 32 animals each (4 animals/group/healing interval). The defect was treated with TATBMP-2/ACS(Absorbable collagen sponge) (TATBMP-2 0.1mg/ml), TAT-HA2-BMP-2/ACS(TAT-HA2-BMP-2 0.1mg/ml), ACS alone or left untreated for surgical control(negative control). The rats were sacrificed at 2 or 8 weeks postsurgery, and the results were evaluated histologically. The results were as follows: New bone formation were not significantly greater in the TATBMP-2/ACS group relative to negative, and positive control groups. New bone was evident at the defect sites in TAT-HA2-BMP-2/ACS group relative to negative, positive control and TATBMP-2 groups. There were a little bone regeneration in TATBMP-2 groups. While, enhanced local bone formation were observed in TAT-HA2-BMP-2 group. But, The results was not the same in all rat defects. Therefore, further investigations are required to develop a method. which disperse homogenously, and adhere to target cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 497~509 | - |
dc.relation.isPartOf | Journal of Korean Academy of Periodontology (대한치주과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Protein transduction domain을 이용한 recombinant human bone morphogenetic protein-2의 골재생효과 | - |
dc.title.alternative | Bone regenerative effects of recombinant human bone morphogenetic protein-2 employed protein transduction domain | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | 정성원 | - |
dc.contributor.googleauthor | 김남희 | - |
dc.contributor.googleauthor | 조규성 | - |
dc.contributor.googleauthor | 김형준 | - |
dc.contributor.googleauthor | 김창성 | - |
dc.contributor.googleauthor | 육종인 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A03810 | - |
dc.relation.journalcode | J01492 | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Kim, Hyung Jun | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 497 | - |
dc.citation.endPage | 509 | - |
dc.identifier.bibliographicCitation | Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.37(3) : 497-509, 2007 | - |
dc.identifier.rimsid | 47718 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.