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대장암에서 Adenosine Triphosphate Based Chemotherapy Response Assay (ATP-CRA)를 이용한 in vitro 항암제 감수성 검사

Other Titles
 In-vitro Chemosensitivity Test for Colorectal Cancer using an Adenosine-triphosphate-based Chemotherapy Response Assay (ATP-CRA) 
Authors
 허정욱  ;  박윤아  ;  최승호  ;  최성호  ;  손승국 
Citation
 Journal of the Korean Society of Coloproctology, Vol.23(3) : 172-177, 2007 
Journal Title
Journal of the Korean Society of Coloproctology(대한대장항문학회지)
ISSN
 2287-9714 
Issue Date
2007
Abstract
Purpose
The adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) is a well-documented and validated technology for individualizing chemotherapy in cancer patients. We evaluate the feasibility of ATP-CRA in colorectal cancer patients. This study will illustrate the assay's success rate, the mean coefficient of variation, and the turnaround time as a validation tool for a chemosensitivity test.

Methods
A total of 118 patients, treated by surgery between June 2004 and September 2005 were evaluated for chemosensitivity to seven anticancer agents (5-fluorouracil (5-FU), oxaliplatin, irinotecan, epirubicin, etoposide, gemcitabine, and paclitaxel) by using an ATP-CRA. To allow a comparison between samples, we calculated the chemosensitivity index (CI) based on the percentage cell death rate (CDR,%) at each test drug concentration.

Results
The assay success rate was 85.5% (118/138), and the mean coefficient of variation, indicating intra-assay error level, was 9.2%. CDR measured at a therapeutic peak plasma concentration ranged from 0% to 93.6% with a median of 31.0% for 5-FU, 28.5% for oxaliplatin, 34.0% for irinotecan, 25.0% for epirubicin, 21.0% for etoposide, 22.0% for gemcitabine, and 25.2% for paclitaxel. According to the CI, the most sensitive drug varied from patient to patients 10.9% for 5-FU, 10.9% for oxaliplatin, 24.7% for irinotecan, 11.8% for epirubicin, 22.4% for etoposide, 1.1% for gemcitabine, and 23.3% for paclitaxel.

Conclusions
Our data suggest that the ATPCRA is a feasible in-vitro chemosensitivity test in colorectal cancer and that patients show heterogeneous chemosensitivity. A study evaluating the predictive value of ATP-CRA directed therapy is needed to determine the clinical usefulness of the test.
Files in This Item:
T200701382.pdf Download
DOI
10.3393/jksc.2007.23.3.172
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yoon Ah(박윤아)
Sohn, Seung Kook(손승국)
Huh, Jung Wook(허정욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97683
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